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Thermoplastic polyurethanes containing poly(dimethylsiloxane): Synthesis, properties and biocompatibility

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2016
bitstream_24084.pdf (4.093Mb)
Authors
Pergal, Marija
Conference object (Published version)
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Abstract
Thermoplastic polyurethane (TPU) materials containing poly(dimethylsiloxane) (PDMS) segments have been used in various medical devices, primarily because of their good mechanical properties and biostability. However, PDMS-based TPUs, currently utilized for biomedical applications, have sub-optimal biocompatibility in terms of resistance to cell adhesion and relatively poor support for endothelial cell growth, which diminishes their efficacy. In order to significantly improve and extend clinical applications of PDMS-based TPUs, the aim of the research was to enhance the endothelial cell attachment and blood-contacting properties of these materials [1,2]. This study is focused on overview of the synthesis, characterization of the structure, surface, thermal, and mechanical properties, as well as investigation of biocompatibility of PDMS-based TPUs. The synthesized PDMS based TPUs exhibit good surface and thermo-mechanical properties, as well as good biocompatibility equal to current comm...ercial biomedical TPUs.

Keywords:
polyurethane / properties / biocompatibility
Source:
Book of Abstracts - 4th Conference of Young Chemists of Serbia, November 5, 2016, Belgrade, Serbia, 2016, 3-3
Publisher:
  • Serbian Chemical Society
Funding / projects:
  • Synthesis and characterization of novel functional polymers and polymeric nanocomposites (RS-172062)

ISBN: 978-86-7132-064-1

[ Google Scholar ]
Handle
https://hdl.handle.net/21.15107/rcub_cer_5826
URI
https://cer.ihtm.bg.ac.rs/handle/123456789/5826
Collections
  • Radovi istraživača / Researchers' publications
Institution/Community
IHTM
TY  - CONF
AU  - Pergal, Marija
PY  - 2016
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/5826
AB  - Thermoplastic polyurethane (TPU) materials containing poly(dimethylsiloxane) (PDMS) segments have been used in various medical devices, primarily because of their good mechanical properties and biostability. However, PDMS-based TPUs, currently utilized for biomedical applications, have sub-optimal biocompatibility in terms of resistance to cell adhesion and relatively poor support for endothelial cell growth, which diminishes their efficacy. In order to significantly improve and extend clinical applications of PDMS-based TPUs, the aim of the research was to enhance the endothelial cell attachment and blood-contacting properties of these materials [1,2]. This study is focused on overview of the synthesis, characterization of the structure, surface, thermal, and mechanical properties, as well as investigation of biocompatibility of PDMS-based TPUs. The synthesized PDMS based TPUs exhibit good surface and thermo-mechanical properties, as well as good biocompatibility equal to current commercial biomedical TPUs.
PB  - Serbian Chemical Society
C3  - Book of Abstracts - 4th Conference of Young Chemists of Serbia, November 5, 2016, Belgrade, Serbia
T1  - Thermoplastic polyurethanes containing poly(dimethylsiloxane): Synthesis, properties and biocompatibility
SP  - 3
EP  - 3
UR  - https://hdl.handle.net/21.15107/rcub_cer_5826
ER  - 
@conference{
author = "Pergal, Marija",
year = "2016",
abstract = "Thermoplastic polyurethane (TPU) materials containing poly(dimethylsiloxane) (PDMS) segments have been used in various medical devices, primarily because of their good mechanical properties and biostability. However, PDMS-based TPUs, currently utilized for biomedical applications, have sub-optimal biocompatibility in terms of resistance to cell adhesion and relatively poor support for endothelial cell growth, which diminishes their efficacy. In order to significantly improve and extend clinical applications of PDMS-based TPUs, the aim of the research was to enhance the endothelial cell attachment and blood-contacting properties of these materials [1,2]. This study is focused on overview of the synthesis, characterization of the structure, surface, thermal, and mechanical properties, as well as investigation of biocompatibility of PDMS-based TPUs. The synthesized PDMS based TPUs exhibit good surface and thermo-mechanical properties, as well as good biocompatibility equal to current commercial biomedical TPUs.",
publisher = "Serbian Chemical Society",
journal = "Book of Abstracts - 4th Conference of Young Chemists of Serbia, November 5, 2016, Belgrade, Serbia",
title = "Thermoplastic polyurethanes containing poly(dimethylsiloxane): Synthesis, properties and biocompatibility",
pages = "3-3",
url = "https://hdl.handle.net/21.15107/rcub_cer_5826"
}
Pergal, M.. (2016). Thermoplastic polyurethanes containing poly(dimethylsiloxane): Synthesis, properties and biocompatibility. in Book of Abstracts - 4th Conference of Young Chemists of Serbia, November 5, 2016, Belgrade, Serbia
Serbian Chemical Society., 3-3.
https://hdl.handle.net/21.15107/rcub_cer_5826
Pergal M. Thermoplastic polyurethanes containing poly(dimethylsiloxane): Synthesis, properties and biocompatibility. in Book of Abstracts - 4th Conference of Young Chemists of Serbia, November 5, 2016, Belgrade, Serbia. 2016;:3-3.
https://hdl.handle.net/21.15107/rcub_cer_5826 .
Pergal, Marija, "Thermoplastic polyurethanes containing poly(dimethylsiloxane): Synthesis, properties and biocompatibility" in Book of Abstracts - 4th Conference of Young Chemists of Serbia, November 5, 2016, Belgrade, Serbia (2016):3-3,
https://hdl.handle.net/21.15107/rcub_cer_5826 .

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