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dc.creatorŠegan, Sandra
dc.creatorOpsenica, Dejan
dc.creatorŠolaja, Bogdan
dc.creatorMilojković-Opsenica, Dušanka
dc.date.accessioned2019-01-30T17:21:12Z
dc.date.available2019-01-30T17:21:12Z
dc.date.issued2009
dc.identifier.issn0933-4173
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/579
dc.description.abstractSeven pairs of cis-trans isomers of bis-steroidal tetraoxanes have been examined by both normal-phase (NP) and reversed-phase (RP) planar chromatography. Unmodified silica gel was used with ethyl acetate-toluene and ethyl acetate-petroleum ether as mobile phases in typical normal-phase systems. CN-silica with the mobile phases methanol-water and acetone-water and RP-18 silica with water-organic modifier (methanol, acetone, or dioxane) mobile phases were used as reversed-phase systems. For the RP systems a good linear correlation was established between R M values and amount ([%] ν/ν ) of organic modifier in the mobile phase (usually r > 0.99). It was found that under both NP and RP conditions cis isomers were more weakly retained than the corresponding trans isomers. The only exception to this was the chromatographic behavior of C(24) methyl esters. It was established that increasing the polarity of substituents at C(24) and C(24a) led to stronger retention in NP systems, i.e. weaker retention in RP systems. Highly selective separation was achieved in all the chromatographic systems investigated. Possible separation mechanisms are discussed on the basis of the results obtained.en
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/142022/RS//
dc.rightsrestrictedAccess
dc.sourceJournal of Planar Chromatography - Modern TLC
dc.subjectBis-Steroidal tetraoxanesen
dc.subjectCis-trans Isomersen
dc.subjectPlanar chromatographyen
dc.subjectSeparation mechanismsen
dc.titlePlanar chromatography of cholic acid-derived cis-trans isomeric bis-steroidal tetraoxanesen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractШолаја, Б.; Милојковић-Опсеница, Д.; Шеган, Сандра; Опсеница, Дејан;
dc.citation.volume22
dc.citation.issue3
dc.citation.spage175
dc.citation.epage181
dc.citation.other22(3): 175-181
dc.citation.rankM23
dc.identifier.doi10.1556/JPC.22.2009.3.3
dc.identifier.rcubConv_4209
dc.identifier.scopus2-s2.0-67650681846
dc.identifier.wos000267615000003
dc.type.versionpublishedVersion


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