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dc.creatorZmejkovski, Bojana
dc.creatorKaluđerović, Goran N.
dc.creatorGómez-Ruiz, S.
dc.creatorŽižak, Željko
dc.creatorSteinborn, D.
dc.creatorSchmidt, H.
dc.creatorPaschke, Reinhard
dc.creatorJuranić, Zorica
dc.creatorSabo, Tibor
dc.date.accessioned2019-01-30T17:21:11Z
dc.date.available2019-01-30T17:21:11Z
dc.date.issued2009
dc.identifier.issn0223-5234
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/578
dc.description.abstractNew R2eddip-type esters (R = cyclopentyl, L3·2HCl 1.5H2O; cyclohexyl, L4·2HCl·H2O) and corresponding palladium(II) complexes, [PdCl2L3] (3) and [PdCl2L4]·H2O (4), as well as [PdCl2L2] (2; L2 diisobutyl ester of eddip) were synthesized and characterized by IR, 1H and 13C NMR spectroscopies and elemental analysis. The crystal structure of L3·2HCl·2CHCl3 was resolved and is given herein. The NMR spectroscopy confirmed the presence of two isomers (from three possible) for each palladium(II) complex. DFT calculations support the formation of two diastereoisomers. In addition, antitumoral investigations were performed and these investigations also included the diisopropyl ester of eddip (L1) and corresponding palladium(II) complex, [PdCl2L1] (1). In vitro antiproliferative activity was determined against several tumor cell lines HeLa, Fem-x, K562 and rested and stimulated normal immunocompetent cells (human peripheral blood mononuclear cells -PBMCs) using MTT test.en
dc.publisherElsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/142010/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/145006/RS//
dc.rightsrestrictedAccess
dc.sourceEuropean Journal of Medicinal Chemistry
dc.subjectAntitumoral activityen
dc.subjectCrystal structureen
dc.subjectDFT calculationsen
dc.subjectEDDA-type ligandsen
dc.subjectPalladium(II) complexesen
dc.titlePalladium(II) complexes with R2edda-derived ligands. Part II. Synthesis, characterization and in vitro antitumoral studies of R2eddip esters and palladium(II) complexesen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractЖижак, З.; Калудеровић, Г.Н.; Змејковски, Бојана; Сабо, Т.Ј.; Пасцхке, Р.; Сцхмидт, Х.; Стеинборн, Д.; Јуранић, З.Д.; Гóмез-Руиз, С.;
dc.citation.volume44
dc.citation.issue9
dc.citation.spage3452
dc.citation.epage3458
dc.citation.other44(9): 3452-3458
dc.citation.rankM21
dc.identifier.pmid19272676
dc.identifier.doi10.1016/j.ejmech.2009.02.002
dc.identifier.rcubConv_4208
dc.identifier.scopus2-s2.0-67650567982
dc.identifier.wos000268744700011
dc.type.versionpublishedVersion


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