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Antimicrobial activities of two copper(Il) complexes with 4-(diethylamino)salicylaldehyde and a-diimine

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2018
A3.7..pdf (3.282Mb)
Authors
Selaković, Snežana
Dimitrijević, Teodora
Novaković, Irena
Šumar Ristović, Maja
Conference object (Published version)
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Abstract
Two novel coppe(tr) complexes (Fig. 1) with 4-(diethylamino)salicylald.hyd. as ligand (HL) and o-diimine - 2,2'-bipyridine (bipy) or 1,lO-phenanthroline (phen) with potentially antimicrobial activity are described. Complex 1 is a mononuclear copper(Il) complex, [Cu(bipy)(L)]BF+.HzO, whereas complex 2 is a binuclear [Cu(phen)(L)]z(BF+)2. Antimicrobial activities of those complexes, coffesponding Cu(II) salt, o,-diimines (phen and bipy) and ligand HL were studied by examining the minimum inhibitory concentration (MIC) on four Gram-positive and four Gram-negative bacterial species and three fungal strains. Amikacin and fluconazole were used as the standard drugs for the comparison of the MIC values. Cu(II) complexes I and 2 demonstrated significantly stronger antibacterial activities than parent ligands (adiimines and HL) or starting Cu(II) salt. Complex 2 is the most active of all examined compounds. The activity of this complex against E. coli is comparable to the activity of the standa...rd antibiotic amikacin. Unlike increasing antibacterial activity of complexes 1 and2 in regard to all coordinated ligands, antifungal activities showed the opposite trend.

Keywords:
antibacterial activity / Cu(II) complexes / antimicrobial activities
Source:
Book of abstracts - Sixth Conference of the Young Chemists of Serbia, 27.10. 2018, Belgrade, 2018, 88-88
Publisher:
  • Belgrade : Serbian Chemical Society
Funding / projects:
  • Interactions of natural products, their derivatives and coordination compounds with proteins and nucleic acids (RS-172055)

ISBN: 978-86-7132-072-6

[ Google Scholar ]
Handle
https://hdl.handle.net/21.15107/rcub_cer_5786
URI
https://cer.ihtm.bg.ac.rs/handle/123456789/5786
Collections
  • Radovi istraživača / Researchers' publications
Institution/Community
IHTM
TY  - CONF
AU  - Selaković, Snežana
AU  - Dimitrijević, Teodora
AU  - Novaković, Irena
AU  - Šumar Ristović, Maja
PY  - 2018
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/5786
AB  - Two novel coppe(tr) complexes (Fig. 1) with 4-(diethylamino)salicylald.hyd. as ligand (HL) and o-diimine - 2,2'-bipyridine (bipy) or 1,lO-phenanthroline (phen) with potentially antimicrobial activity are described. Complex 1 is a mononuclear copper(Il) complex, [Cu(bipy)(L)]BF+.HzO, whereas complex 2 is a binuclear [Cu(phen)(L)]z(BF+)2. Antimicrobial activities of those complexes, coffesponding Cu(II) salt, o,-diimines (phen and bipy) and ligand HL were studied by examining the minimum inhibitory concentration (MIC) on four Gram-positive and four Gram-negative bacterial species and three fungal strains. Amikacin and fluconazole were used as the standard drugs for the comparison of the MIC values. Cu(II) complexes I and 2 demonstrated significantly stronger antibacterial activities than parent ligands (adiimines and HL) or starting Cu(II) salt. Complex 2 is the most active of all examined compounds. The activity of this complex against E. coli is comparable to the activity of the standard antibiotic amikacin. Unlike increasing antibacterial activity of complexes 1 and2 in regard to all coordinated ligands, antifungal activities showed the opposite trend.
PB  - Belgrade : Serbian Chemical Society
C3  - Book of abstracts - Sixth Conference of the Young Chemists of Serbia, 27.10. 2018, Belgrade
T1  - Antimicrobial activities of two copper(Il) complexes with 4-(diethylamino)salicylaldehyde and a-diimine
SP  - 88
EP  - 88
UR  - https://hdl.handle.net/21.15107/rcub_cer_5786
ER  - 
@conference{
author = "Selaković, Snežana and Dimitrijević, Teodora and Novaković, Irena and Šumar Ristović, Maja",
year = "2018",
abstract = "Two novel coppe(tr) complexes (Fig. 1) with 4-(diethylamino)salicylald.hyd. as ligand (HL) and o-diimine - 2,2'-bipyridine (bipy) or 1,lO-phenanthroline (phen) with potentially antimicrobial activity are described. Complex 1 is a mononuclear copper(Il) complex, [Cu(bipy)(L)]BF+.HzO, whereas complex 2 is a binuclear [Cu(phen)(L)]z(BF+)2. Antimicrobial activities of those complexes, coffesponding Cu(II) salt, o,-diimines (phen and bipy) and ligand HL were studied by examining the minimum inhibitory concentration (MIC) on four Gram-positive and four Gram-negative bacterial species and three fungal strains. Amikacin and fluconazole were used as the standard drugs for the comparison of the MIC values. Cu(II) complexes I and 2 demonstrated significantly stronger antibacterial activities than parent ligands (adiimines and HL) or starting Cu(II) salt. Complex 2 is the most active of all examined compounds. The activity of this complex against E. coli is comparable to the activity of the standard antibiotic amikacin. Unlike increasing antibacterial activity of complexes 1 and2 in regard to all coordinated ligands, antifungal activities showed the opposite trend.",
publisher = "Belgrade : Serbian Chemical Society",
journal = "Book of abstracts - Sixth Conference of the Young Chemists of Serbia, 27.10. 2018, Belgrade",
title = "Antimicrobial activities of two copper(Il) complexes with 4-(diethylamino)salicylaldehyde and a-diimine",
pages = "88-88",
url = "https://hdl.handle.net/21.15107/rcub_cer_5786"
}
Selaković, S., Dimitrijević, T., Novaković, I.,& Šumar Ristović, M.. (2018). Antimicrobial activities of two copper(Il) complexes with 4-(diethylamino)salicylaldehyde and a-diimine. in Book of abstracts - Sixth Conference of the Young Chemists of Serbia, 27.10. 2018, Belgrade
Belgrade : Serbian Chemical Society., 88-88.
https://hdl.handle.net/21.15107/rcub_cer_5786
Selaković S, Dimitrijević T, Novaković I, Šumar Ristović M. Antimicrobial activities of two copper(Il) complexes with 4-(diethylamino)salicylaldehyde and a-diimine. in Book of abstracts - Sixth Conference of the Young Chemists of Serbia, 27.10. 2018, Belgrade. 2018;:88-88.
https://hdl.handle.net/21.15107/rcub_cer_5786 .
Selaković, Snežana, Dimitrijević, Teodora, Novaković, Irena, Šumar Ristović, Maja, "Antimicrobial activities of two copper(Il) complexes with 4-(diethylamino)salicylaldehyde and a-diimine" in Book of abstracts - Sixth Conference of the Young Chemists of Serbia, 27.10. 2018, Belgrade (2018):88-88,
https://hdl.handle.net/21.15107/rcub_cer_5786 .

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