Antimicrobial activities of two copper(Il) complexes with 4-(diethylamino)salicylaldehyde and a-diimine
Abstract
Two novel coppe(tr) complexes (Fig. 1) with 4-(diethylamino)salicylald.hyd. as ligand (HL) and o-diimine - 2,2'-bipyridine (bipy) or 1,lO-phenanthroline (phen) with potentially antimicrobial activity are described. Complex 1 is a mononuclear copper(Il) complex, [Cu(bipy)(L)]BF+.HzO, whereas complex 2 is a binuclear [Cu(phen)(L)]z(BF+)2. Antimicrobial activities of those complexes, coffesponding Cu(II) salt, o,-diimines (phen and bipy) and ligand HL were studied by examining the minimum inhibitory concentration (MIC) on four Gram-positive and four Gram-negative bacterial species and three fungal strains. Amikacin and fluconazole were used as the standard drugs for the comparison of the MIC values. Cu(II) complexes I and 2 demonstrated significantly stronger antibacterial activities than parent ligands (adiimines and HL) or starting Cu(II) salt. Complex 2 is the most active of all examined compounds. The activity of this complex against E. coli is comparable to the activity of the standa...rd antibiotic amikacin. Unlike increasing antibacterial activity of complexes 1 and2 in regard to all coordinated ligands, antifungal activities showed the opposite trend.
Keywords:
antibacterial activity / Cu(II) complexes / antimicrobial activitiesSource:
Book of abstracts - Sixth Conference of the Young Chemists of Serbia, 27.10. 2018, Belgrade, 2018, 88-88Publisher:
- Belgrade : Serbian Chemical Society
Funding / projects:
Collections
Institution/Community
IHTMTY - CONF AU - Selaković, Snežana AU - Dimitrijević, Teodora AU - Novaković, Irena AU - Šumar Ristović, Maja PY - 2018 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/5786 AB - Two novel coppe(tr) complexes (Fig. 1) with 4-(diethylamino)salicylald.hyd. as ligand (HL) and o-diimine - 2,2'-bipyridine (bipy) or 1,lO-phenanthroline (phen) with potentially antimicrobial activity are described. Complex 1 is a mononuclear copper(Il) complex, [Cu(bipy)(L)]BF+.HzO, whereas complex 2 is a binuclear [Cu(phen)(L)]z(BF+)2. Antimicrobial activities of those complexes, coffesponding Cu(II) salt, o,-diimines (phen and bipy) and ligand HL were studied by examining the minimum inhibitory concentration (MIC) on four Gram-positive and four Gram-negative bacterial species and three fungal strains. Amikacin and fluconazole were used as the standard drugs for the comparison of the MIC values. Cu(II) complexes I and 2 demonstrated significantly stronger antibacterial activities than parent ligands (adiimines and HL) or starting Cu(II) salt. Complex 2 is the most active of all examined compounds. The activity of this complex against E. coli is comparable to the activity of the standard antibiotic amikacin. Unlike increasing antibacterial activity of complexes 1 and2 in regard to all coordinated ligands, antifungal activities showed the opposite trend. PB - Belgrade : Serbian Chemical Society C3 - Book of abstracts - Sixth Conference of the Young Chemists of Serbia, 27.10. 2018, Belgrade T1 - Antimicrobial activities of two copper(Il) complexes with 4-(diethylamino)salicylaldehyde and a-diimine SP - 88 EP - 88 UR - https://hdl.handle.net/21.15107/rcub_cer_5786 ER -
@conference{ author = "Selaković, Snežana and Dimitrijević, Teodora and Novaković, Irena and Šumar Ristović, Maja", year = "2018", abstract = "Two novel coppe(tr) complexes (Fig. 1) with 4-(diethylamino)salicylald.hyd. as ligand (HL) and o-diimine - 2,2'-bipyridine (bipy) or 1,lO-phenanthroline (phen) with potentially antimicrobial activity are described. Complex 1 is a mononuclear copper(Il) complex, [Cu(bipy)(L)]BF+.HzO, whereas complex 2 is a binuclear [Cu(phen)(L)]z(BF+)2. Antimicrobial activities of those complexes, coffesponding Cu(II) salt, o,-diimines (phen and bipy) and ligand HL were studied by examining the minimum inhibitory concentration (MIC) on four Gram-positive and four Gram-negative bacterial species and three fungal strains. Amikacin and fluconazole were used as the standard drugs for the comparison of the MIC values. Cu(II) complexes I and 2 demonstrated significantly stronger antibacterial activities than parent ligands (adiimines and HL) or starting Cu(II) salt. Complex 2 is the most active of all examined compounds. The activity of this complex against E. coli is comparable to the activity of the standard antibiotic amikacin. Unlike increasing antibacterial activity of complexes 1 and2 in regard to all coordinated ligands, antifungal activities showed the opposite trend.", publisher = "Belgrade : Serbian Chemical Society", journal = "Book of abstracts - Sixth Conference of the Young Chemists of Serbia, 27.10. 2018, Belgrade", title = "Antimicrobial activities of two copper(Il) complexes with 4-(diethylamino)salicylaldehyde and a-diimine", pages = "88-88", url = "https://hdl.handle.net/21.15107/rcub_cer_5786" }
Selaković, S., Dimitrijević, T., Novaković, I.,& Šumar Ristović, M.. (2018). Antimicrobial activities of two copper(Il) complexes with 4-(diethylamino)salicylaldehyde and a-diimine. in Book of abstracts - Sixth Conference of the Young Chemists of Serbia, 27.10. 2018, Belgrade Belgrade : Serbian Chemical Society., 88-88. https://hdl.handle.net/21.15107/rcub_cer_5786
Selaković S, Dimitrijević T, Novaković I, Šumar Ristović M. Antimicrobial activities of two copper(Il) complexes with 4-(diethylamino)salicylaldehyde and a-diimine. in Book of abstracts - Sixth Conference of the Young Chemists of Serbia, 27.10. 2018, Belgrade. 2018;:88-88. https://hdl.handle.net/21.15107/rcub_cer_5786 .
Selaković, Snežana, Dimitrijević, Teodora, Novaković, Irena, Šumar Ristović, Maja, "Antimicrobial activities of two copper(Il) complexes with 4-(diethylamino)salicylaldehyde and a-diimine" in Book of abstracts - Sixth Conference of the Young Chemists of Serbia, 27.10. 2018, Belgrade (2018):88-88, https://hdl.handle.net/21.15107/rcub_cer_5786 .