One-step conversion of ketones to conjugated acids using bromoform
Authorized Users Only
2009
Authors
Vitnik, Vesna
Ivanović, Milovan D.

Vitnik, Željko

Đorđević, Jelena B.

Žižak, Željko

Juranić, Zorica

Juranić, Ivan

Article (Published version)

Metadata
Show full item recordAbstract
Phase-transfer-catalyzed (PTC) reactions of ketones with bromoform and aqueous lithium hydroxide in alcoholic solvent result in the formation of ,-unsaturated carboxylic acids. The reaction was performed at room temperature for 24h. The corresponding conjugated acids were obtained from cyclic or aromatic ketones, whereas bromo acids were obtained from 4-oxo-piperidine-1- carboxylic acid ethyl ester (13) and 4-oxo-piperidine-1-carboxylic acid tert-butyl ester (14).
Keywords:
,-unsaturated carboxylic acids / Bromoform / phase-transfer-catalyzed reactionSource:
Synthetic Communications, 2009, 39, 8, 1457-1471Projects:
- Novi sintetički pristupi, molekulsko modelovanje i farmakološko ispitivanje heterocikličnih sistema sa azotom (RS-142074)
- Synthesis, characterization and activity of organic and coordination composition and their application in (bio) nanotechnology (RS-142010)
DOI: 10.1080/00397910802531955
ISSN: 0039-7911