Analysis of the Time Response of Chemical and Biological Microfluidic Sensors with a Micro/Nanoscale Active Surface

Abstract

After a review of a deterministic model of time response of microfluidic adsorption-based chemical and biological sensors, we present an approximate model for efficient analysis of stochastic response, which takes into account a random AD process coupled with convection and diffusion of target substance particles. Subsequently, we present the results obtained by the comparison of the two response models (deterministic and stochastic) used for sensors with different micro/nanoscale active surfaces, and intended for detection of substances present in different concentrations. In this way we can distinguish the cases in which the use of the deterministic model is justified from those in which the use of the stochastic model is necessary. The presented findings enable more accurate interpretation of measurement results obtained by using sensors with micro/nanoscale active surface, as well as optimization of their design.