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Eu2O3@Cr2O3 Nanoparticles-Modified Carbon Paste Electrode for Efficient Electrochemical Sensing of Neurotransmitters Precursor L-DOPA
dc.creator | Mijajlović, Aleksandar | |
dc.creator | Ognjanović, Miloš | |
dc.creator | Manojlović, Dragan | |
dc.creator | Vlahović, Filip | |
dc.creator | Ðurđić, Slađana | |
dc.creator | Stanković, Vesna | |
dc.creator | Stanković, Dalibor | |
dc.date.accessioned | 2023-02-16T11:16:43Z | |
dc.date.available | 2023-02-16T11:16:43Z | |
dc.date.issued | 2023 | |
dc.identifier.issn | 2079-6374 | |
dc.identifier.uri | https://cer.ihtm.bg.ac.rs/handle/123456789/5694 | |
dc.description.abstract | There are ten million people in the world who have Parkinson’s disease. The most potent medicine for Parkinson’s disease is levodopa (L-DOPA). However, long-term consumption of L-DOPA leads to the appearance of side effects, as a result of which the control and monitoring of its concentrations are of great importance. In this work, we have designed a new electrochemical sensor for detecting L-DOPA using a carbon paste electrode (CPE) modified with Eu2O3@Cr2O3 composite nanoparticles. Rare earth elements, including Eu, are increasingly used to design new electrode nanocomposites with enhanced electrocatalytic properties. Europium has been considered a significant lanthanide element with greater redox reaction behavior. We conducted a hydrothermal synthesis of Eu2O3@Cr2O3 and, for the first time, the acquired nanoparticles were used to modify CPE. The proposed Eu2O3@Cr2O3/CPE electrode was investigated in terms of its electrocatalytic properties and then used to develop an analytical method for detecting and quantifying L-DOPA. The proposed sensor offers a wide linear range (1–100 µM), high sensitivity (1.38 µA µM−1 cm−2) and a low detection limit (0.72 µM). The practical application of the proposed sensor was investigated by analyzing commercially available pharmaceutical tablets of L-DOPA. The corresponding results indicate the excellent potential of the Eu2O3@Cr2O3/CPE sensor for application in real-time L-DOPA detection. | sr |
dc.language.iso | en | sr |
dc.publisher | Switzerland : Multidisciplinary Digital Publishing Institute (MDPI) | sr |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200168/RS// | sr |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200026/RS// | sr |
dc.relation | The Eureka project E! 13303 MED-BIO-TEST (contract number 451-03-00053/2020-09/2/2) | sr |
dc.rights | openAccess | sr |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.source | Biosensors | sr |
dc.subject | levodopa | sr |
dc.subject | electrochemical sensor | sr |
dc.subject | rare earth nanomaterial | sr |
dc.subject | hydrothermal synthesis | sr |
dc.subject | micromolar detection | sr |
dc.title | Eu2O3@Cr2O3 Nanoparticles-Modified Carbon Paste Electrode for Efficient Electrochemical Sensing of Neurotransmitters Precursor L-DOPA | sr |
dc.type | article | sr |
dc.rights.license | BY | sr |
dc.citation.volume | 13 | |
dc.citation.issue | 2 | |
dc.citation.spage | 201 | |
dc.citation.rank | M21~ | |
dc.identifier.doi | 10.3390/bios13020201 | |
dc.identifier.fulltext | http://cer.ihtm.bg.ac.rs/bitstream/id/23739/biosensors-13-00201.pdf | |
dc.type.version | publishedVersion | sr |