Lipophilicity of some guaianolides isolated from two endemic subspecies of Amphoricarpos neumayeri (Asteraceae) from Montenegro
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2009
Authors
Atrrog, A.A.B.Natić, Maja
Tosti, Tomislav
Milojković-Opsenica, Dušanka
Dordević, I.
Tešević, Vele
Jadranin, Milka
Milosavljević, Slobodan
Lazić, M.
Radulović, Siniša
Tešić, Živoslav
Article (Published version)
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In this study 10 guaianolide-type sesquiterpene γ-lactones named amphoricarpolides, isolated from the aerial parts of two endemic subspecies of Amphoricarpos neumayeri (ssp. neumayeri and ssp. murbeckii Bosnjak), were investigated by means of reversed-phase thin-layer chromatography. Methanol-water and tetrahydrofuran-water binary mixtures were used as mobile phase in order to determine lipophilicity parameters and C0. Some of the investigated compounds were screened for their cytotoxic activity against HeLa and B16 cells. Chromatographically obtained lipophilicity parameters were correlated with calculated logP values and IC50 values. Principal component analysis identified the dominant pattern in the chromatographically obtained data. Copyright
Keywords:
Guaianolides / Lipophilicity / PCA / Reversed-phase thin-layer chromatography / Structure-activity relationshipSource:
Biomedical Chromatography, 2009, 23, 3, 250-256Funding / projects:
- Sinteza, analiza i aktivnost novih organskih polidentatnih liganada i njihovih kompleksa sa d-metalima (RS-MESTD-MPN2006-2010-142062)
DOI: 10.1002/bmc.1091
ISSN: 0269-3879
PubMed: 18816478
WoS: 000263776700003
Scopus: 2-s2.0-65249100236
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IHTMTY - JOUR AU - Atrrog, A.A.B. AU - Natić, Maja AU - Tosti, Tomislav AU - Milojković-Opsenica, Dušanka AU - Dordević, I. AU - Tešević, Vele AU - Jadranin, Milka AU - Milosavljević, Slobodan AU - Lazić, M. AU - Radulović, Siniša AU - Tešić, Živoslav PY - 2009 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/567 AB - In this study 10 guaianolide-type sesquiterpene γ-lactones named amphoricarpolides, isolated from the aerial parts of two endemic subspecies of Amphoricarpos neumayeri (ssp. neumayeri and ssp. murbeckii Bosnjak), were investigated by means of reversed-phase thin-layer chromatography. Methanol-water and tetrahydrofuran-water binary mixtures were used as mobile phase in order to determine lipophilicity parameters and C0. Some of the investigated compounds were screened for their cytotoxic activity against HeLa and B16 cells. Chromatographically obtained lipophilicity parameters were correlated with calculated logP values and IC50 values. Principal component analysis identified the dominant pattern in the chromatographically obtained data. Copyright T2 - Biomedical Chromatography T1 - Lipophilicity of some guaianolides isolated from two endemic subspecies of Amphoricarpos neumayeri (Asteraceae) from Montenegro VL - 23 IS - 3 SP - 250 EP - 256 DO - 10.1002/bmc.1091 ER -
@article{ author = "Atrrog, A.A.B. and Natić, Maja and Tosti, Tomislav and Milojković-Opsenica, Dušanka and Dordević, I. and Tešević, Vele and Jadranin, Milka and Milosavljević, Slobodan and Lazić, M. and Radulović, Siniša and Tešić, Živoslav", year = "2009", abstract = "In this study 10 guaianolide-type sesquiterpene γ-lactones named amphoricarpolides, isolated from the aerial parts of two endemic subspecies of Amphoricarpos neumayeri (ssp. neumayeri and ssp. murbeckii Bosnjak), were investigated by means of reversed-phase thin-layer chromatography. Methanol-water and tetrahydrofuran-water binary mixtures were used as mobile phase in order to determine lipophilicity parameters and C0. Some of the investigated compounds were screened for their cytotoxic activity against HeLa and B16 cells. Chromatographically obtained lipophilicity parameters were correlated with calculated logP values and IC50 values. Principal component analysis identified the dominant pattern in the chromatographically obtained data. Copyright", journal = "Biomedical Chromatography", title = "Lipophilicity of some guaianolides isolated from two endemic subspecies of Amphoricarpos neumayeri (Asteraceae) from Montenegro", volume = "23", number = "3", pages = "250-256", doi = "10.1002/bmc.1091" }
Atrrog, A.A.B., Natić, M., Tosti, T., Milojković-Opsenica, D., Dordević, I., Tešević, V., Jadranin, M., Milosavljević, S., Lazić, M., Radulović, S.,& Tešić, Ž.. (2009). Lipophilicity of some guaianolides isolated from two endemic subspecies of Amphoricarpos neumayeri (Asteraceae) from Montenegro. in Biomedical Chromatography, 23(3), 250-256. https://doi.org/10.1002/bmc.1091
Atrrog A, Natić M, Tosti T, Milojković-Opsenica D, Dordević I, Tešević V, Jadranin M, Milosavljević S, Lazić M, Radulović S, Tešić Ž. Lipophilicity of some guaianolides isolated from two endemic subspecies of Amphoricarpos neumayeri (Asteraceae) from Montenegro. in Biomedical Chromatography. 2009;23(3):250-256. doi:10.1002/bmc.1091 .
Atrrog, A.A.B., Natić, Maja, Tosti, Tomislav, Milojković-Opsenica, Dušanka, Dordević, I., Tešević, Vele, Jadranin, Milka, Milosavljević, Slobodan, Lazić, M., Radulović, Siniša, Tešić, Živoslav, "Lipophilicity of some guaianolides isolated from two endemic subspecies of Amphoricarpos neumayeri (Asteraceae) from Montenegro" in Biomedical Chromatography, 23, no. 3 (2009):250-256, https://doi.org/10.1002/bmc.1091 . .