In this study 10 guaianolide-type sesquiterpene γ-lactones named amphoricarpolides, isolated from the aerial parts of two endemic subspecies of Amphoricarpos neumayeri (ssp. neumayeri and ssp. murbeckii Bosnjak), were investigated by means of reversed-phase thin-layer chromatography. Methanol-water and tetrahydrofuran-water binary mixtures were used as mobile phase in order to determine lipophilicity parameters and C0. Some of the investigated compounds were screened for their cytotoxic activity against HeLa and B16 cells. Chromatographically obtained lipophilicity parameters were correlated with calculated logP values and IC50 values. Principal component analysis identified the dominant pattern in the chromatographically obtained data. Copyright
TY - JOUR
AU - Atrrog, A.A.B.
AU - Natić, Maja
AU - Tosti, Tomislav
AU - Milojković-Opsenica, Dušanka
AU - Dordević, I.
AU - Tešević, Vele
AU - Jadranin, Milka
AU - Milosavljević, Slobodan
AU - Lazić, M.
AU - Radulović, Siniša
AU - Tešić, Živoslav
PY - 2009
UR - http://cer.ihtm.bg.ac.rs/handle/123456789/567
AB - In this study 10 guaianolide-type sesquiterpene γ-lactones named amphoricarpolides, isolated from the aerial parts of two endemic subspecies of Amphoricarpos neumayeri (ssp. neumayeri and ssp. murbeckii Bosnjak), were investigated by means of reversed-phase thin-layer chromatography. Methanol-water and tetrahydrofuran-water binary mixtures were used as mobile phase in order to determine lipophilicity parameters and C0. Some of the investigated compounds were screened for their cytotoxic activity against HeLa and B16 cells. Chromatographically obtained lipophilicity parameters were correlated with calculated logP values and IC50 values. Principal component analysis identified the dominant pattern in the chromatographically obtained data. Copyright
T2 - Biomedical Chromatography
T1 - Lipophilicity of some guaianolides isolated from two endemic subspecies of Amphoricarpos neumayeri (Asteraceae) from Montenegro
VL - 23
IS - 3
SP - 250
EP - 256
DO - 10.1002/bmc.1091
ER -
@article{
author = "Atrrog, A.A.B. and Natić, Maja and Tosti, Tomislav and Milojković-Opsenica, Dušanka and Dordević, I. and Tešević, Vele and Jadranin, Milka and Milosavljević, Slobodan and Lazić, M. and Radulović, Siniša and Tešić, Živoslav",
year = "2009",
url = "http://cer.ihtm.bg.ac.rs/handle/123456789/567",
abstract = "In this study 10 guaianolide-type sesquiterpene γ-lactones named amphoricarpolides, isolated from the aerial parts of two endemic subspecies of Amphoricarpos neumayeri (ssp. neumayeri and ssp. murbeckii Bosnjak), were investigated by means of reversed-phase thin-layer chromatography. Methanol-water and tetrahydrofuran-water binary mixtures were used as mobile phase in order to determine lipophilicity parameters and C0. Some of the investigated compounds were screened for their cytotoxic activity against HeLa and B16 cells. Chromatographically obtained lipophilicity parameters were correlated with calculated logP values and IC50 values. Principal component analysis identified the dominant pattern in the chromatographically obtained data. Copyright",
journal = "Biomedical Chromatography",
title = "Lipophilicity of some guaianolides isolated from two endemic subspecies of Amphoricarpos neumayeri (Asteraceae) from Montenegro",
volume = "23",
number = "3",
pages = "250-256",
doi = "10.1002/bmc.1091"
}
Atrrog, A.A.B., Natić, M., Tosti, T., Milojković-Opsenica, D., Dordević, I., Tešević, V., Jadranin, M., Milosavljević, S., Lazić, M., Radulović, S.,& Tešić, Ž. (2009). Lipophilicity of some guaianolides isolated from two endemic subspecies of Amphoricarpos neumayeri (Asteraceae) from Montenegro.
Biomedical Chromatography, 23(3), 250-256.
https://doi.org/10.1002/bmc.1091
Atrrog A, Natić M, Tosti T, Milojković-Opsenica D, Dordević I, Tešević V, Jadranin M, Milosavljević S, Lazić M, Radulović S, Tešić Ž. Lipophilicity of some guaianolides isolated from two endemic subspecies of Amphoricarpos neumayeri (Asteraceae) from Montenegro. Biomedical Chromatography. 2009;23(3):250-256
Atrrog A.A.B., Natić Maja, Tosti Tomislav, Milojković-Opsenica Dušanka, Dordević I., Tešević Vele, Jadranin Milka, Milosavljević Slobodan, Lazić M., Radulović Siniša, Tešić Živoslav, "Lipophilicity of some guaianolides isolated from two endemic subspecies of Amphoricarpos neumayeri (Asteraceae) from Montenegro" Biomedical Chromatography, 23, no. 3 (2009):250-256,
https://doi.org/10.1002/bmc.1091 .
