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Lipophilicity of some guaianolides isolated from two endemic subspecies of Amphoricarpos neumayeri (Asteraceae) from Montenegro

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2009
Authors
Atrrog, A.A.B.
Natić, Maja
Tosti, Tomislav
Milojković-Opsenica, Dušanka
Dordević, I.
Tešević, Vele
Jadranin, Milka
Milosavljević, Slobodan
Lazić, M.
Radulović, Siniša
Tešić, Živoslav
Article (Published version)
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Abstract
In this study 10 guaianolide-type sesquiterpene γ-lactones named amphoricarpolides, isolated from the aerial parts of two endemic subspecies of Amphoricarpos neumayeri (ssp. neumayeri and ssp. murbeckii Bosnjak), were investigated by means of reversed-phase thin-layer chromatography. Methanol-water and tetrahydrofuran-water binary mixtures were used as mobile phase in order to determine lipophilicity parameters and C0. Some of the investigated compounds were screened for their cytotoxic activity against HeLa and B16 cells. Chromatographically obtained lipophilicity parameters were correlated with calculated logP values and IC50 values. Principal component analysis identified the dominant pattern in the chromatographically obtained data. Copyright
Keywords:
Guaianolides / Lipophilicity / PCA / Reversed-phase thin-layer chromatography / Structure-activity relationship
Source:
Biomedical Chromatography, 2009, 23, 3, 250-256
Projects:
  • Sinteza, analiza i aktivnost novih organskih polidentatnih liganada i njihovih kompleksa sa d-metalima (RS-142062)

DOI: 10.1002/bmc.1091

ISSN: 0269-3879

PubMed: 18816478

WoS: 000263776700003

Scopus: 2-s2.0-65249100236
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URI
http://cer.ihtm.bg.ac.rs/handle/123456789/567
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