Приказ основних података о документу

dc.creatorAnđelković, Boban
dc.creatorGođevac, Dejan
dc.creatorStanković, Jovana
dc.creatorCvetković, Mirjana
dc.creatorTešević, Vele
dc.creatorMilosavljević, Slobodan
dc.creatorSimić, Katarina
dc.date.accessioned2023-01-03T13:14:56Z
dc.date.available2023-01-03T13:14:56Z
dc.date.issued2021
dc.identifier.isbn978-989-53350-0-8
dc.identifier.urihttps://cer.ihtm.bg.ac.rs/handle/123456789/5526
dc.description.abstractA large number of plant metabolites has provided an incomparable chemical source of the pharmaceutical products. The two major fields of chemical research on biological active small molecules, metabolomics and natural product discovery, have the similar goals of identifying and characterizing small molecules, either in their isolated active state (natural product chemistry). Metabolomics generate a profile of small molecules from plant extracts, which could be directly responsible for bioactivity effects. Using dry-column flash chromatography enable a rapid and inexpensive method for the very efficient separation of plant extract with a high resolution. This separation method coupled to NMR and FTIR-based metabolomics is applied to identify bioactive natural products. OPLS multivariate analysis method, was used for correlation the chemical composition of the plant extracts, Amphoricarpos autariatus, with the results of cytotoxic activity against Human cervical adenocarcinoma cell line (HeLa) and epithelial lung cancer cell line (A549). In this way, the highest contribution to the cytotoxic activity was recorded for the guaianolide sesquiterpene lactone were tested, and their cytotoxic activity were conformed.sr
dc.language.isoensr
dc.publisherPortugal : PROTEOMASS Scientific Societysr
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200168/RS//sr
dc.rightsopenAccesssr
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceBook of abstracts - 5th International Caparica Christmas Conference on Sample Treatment (ST 2021), 15th – 18th November 2021, Caparica, Portugalsr
dc.subjectplant metabolitessr
dc.subjectNMRsr
dc.subjectFTIRsr
dc.subjectmetabolomicssr
dc.titleIntegration of dry-column flash chromatography with NMR and FTIR metabolomics to reveal cytotoxic metabolites from Amphoricarpos autariatussr
dc.typeconferenceObjectsr
dc.rights.licenseBYsr
dc.rights.holderBIOSCOPE Research Group | PROTEOMASS Scientific Societysr
dc.citation.spage148
dc.citation.epage148
dc.identifier.rcubhttps://hdl.handle.net/21.15107/rcub_cer_5526
dc.identifier.fulltexthttp://cer.ihtm.bg.ac.rs/bitstream/id/23300/bitstream_23300.pdf
dc.type.versionpublishedVersionsr


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