Advances, during the period 2008–18, in the chemistry of 1,2-dithioles as well as their applications in medicine and technology are presented. Additionally, for the better understanding of the extent of recent progress as well as a more complete overview of the topics, the chapter also includes a critical summary of the most relevant previously reported work concerning this subject. The examples of the synthesis of different 1,2-dithioles, starting from various fragments, are described herein following a systematic classification. Their reactivity is also thoroughly reviewed. The significance of lipoic acid, which has been also called a “universal antioxidant,” in the development of the multitarget profile drugs against Alzheimer's disease (AD) and its application for the preparation of functionalized nanoparticles is summarized. A survey of the literature data on the theoretical and experimental study of antioxidant properties of LA as well as its biochemistry is presented. The natura...l occurrence of compounds containing 1,2-dithioles is reviewed. Novel X-ray determinations of structures containing 1,2-dithiole moiety are listed. The synthesis and structure characterization of 3,3aλ4,4-trithia-1-azapentalenes is thoroughly discussed.
TY - CHAP
AU - Rašović, Aleksandar
PY - 2022
UR - https://cer.ihtm.bg.ac.rs/handle/123456789/5514
AB - Advances, during the period 2008–18, in the chemistry of 1,2-dithioles as well as their applications in medicine and technology are presented. Additionally, for the better understanding of the extent of recent progress as well as a more complete overview of the topics, the chapter also includes a critical summary of the most relevant previously reported work concerning this subject. The examples of the synthesis of different 1,2-dithioles, starting from various fragments, are described herein following a systematic classification. Their reactivity is also thoroughly reviewed. The significance of lipoic acid, which has been also called a “universal antioxidant,” in the development of the multitarget profile drugs against Alzheimer's disease (AD) and its application for the preparation of functionalized nanoparticles is summarized. A survey of the literature data on the theoretical and experimental study of antioxidant properties of LA as well as its biochemistry is presented. The natural occurrence of compounds containing 1,2-dithioles is reviewed. Novel X-ray determinations of structures containing 1,2-dithiole moiety are listed. The synthesis and structure characterization of 3,3aλ4,4-trithia-1-azapentalenes is thoroughly discussed.
PB - Elsevier
T2 - Comprehensive Heterocyclic Chemistry IV
T1 - 1,2-Dithioles
VL - 4
SP - 766
EP - 833
DO - 10.1016/B978-0-12-818655-8.00137-2
ER -
@inbook{
author = "Rašović, Aleksandar",
year = "2022",
abstract = "Advances, during the period 2008–18, in the chemistry of 1,2-dithioles as well as their applications in medicine and technology are presented. Additionally, for the better understanding of the extent of recent progress as well as a more complete overview of the topics, the chapter also includes a critical summary of the most relevant previously reported work concerning this subject. The examples of the synthesis of different 1,2-dithioles, starting from various fragments, are described herein following a systematic classification. Their reactivity is also thoroughly reviewed. The significance of lipoic acid, which has been also called a “universal antioxidant,” in the development of the multitarget profile drugs against Alzheimer's disease (AD) and its application for the preparation of functionalized nanoparticles is summarized. A survey of the literature data on the theoretical and experimental study of antioxidant properties of LA as well as its biochemistry is presented. The natural occurrence of compounds containing 1,2-dithioles is reviewed. Novel X-ray determinations of structures containing 1,2-dithiole moiety are listed. The synthesis and structure characterization of 3,3aλ4,4-trithia-1-azapentalenes is thoroughly discussed.",
publisher = "Elsevier",
journal = "Comprehensive Heterocyclic Chemistry IV",
booktitle = "1,2-Dithioles",
volume = "4",
pages = "766-833",
doi = "10.1016/B978-0-12-818655-8.00137-2"
}
Rašović, A.. (2022). 1,2-Dithioles. in Comprehensive Heterocyclic Chemistry IV
Elsevier., 4, 766-833.
https://doi.org/10.1016/B978-0-12-818655-8.00137-2
Rašović A. 1,2-Dithioles. in Comprehensive Heterocyclic Chemistry IV. 2022;4:766-833.
doi:10.1016/B978-0-12-818655-8.00137-2 .
Rašović, Aleksandar, "1,2-Dithioles" in Comprehensive Heterocyclic Chemistry IV, 4 (2022):766-833,
https://doi.org/10.1016/B978-0-12-818655-8.00137-2 . .
