Homology modeling of protein structure
Homologo modelovanje strukture proteina
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Knowledge of three-dimensional protein structure is of the paramount importance for determination of receptor and enzyme action mechanism in interaction with other molecules. In spite of growing number of solved 3D protein structures, number of determined protein sequences exceeds by far the number of defined spatial protein structures. Besides, sequence databases grow more rapidly then databases of 3D protein structures. When crystal protein structures or data obtained by NMR are not available, we have to reach for next 'best' possible solution - modeling of the protein spatial structure. One of the aspects that can be applied to obtain usable protein model is homology modeling. This method is based on the design of the three-dimensional structure of the unknown protein based on layout of the homolog protein of known 3D structure. To get a big picture of this method, in this text, we explained few aspects of homology modeling.
Source:Hemijski pregled, 2009, 50, 2, 30-38
- Srpsko hemijsko društvo, Beograd