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dc.creatorAraškov, Jovana B.
dc.creatorVišnjevac, Aleksandar
dc.creatorPopović, Jasminka
dc.creatorBlagojević, Vladimir
dc.creatorFernandes, Henrique S.
dc.creatorSousa, Sérgio F.
dc.creatorNovaković, Irena
dc.creatorPadrón, José M.
dc.creatorHolló, Berta Barta
dc.creatorMonge, Miguel
dc.creatorRodríguez-Castillo, María
dc.creatorLópez-De-Luzuriaga, José M.
dc.creatorFilipović, Nenad
dc.creatorTodorović, Tamara
dc.date.accessioned2022-12-06T16:22:59Z
dc.date.available2022-12-06T16:22:59Z
dc.date.issued2022
dc.identifier.issn1466-8033
dc.identifier.urihttps://cer.ihtm.bg.ac.rs/handle/123456789/5431
dc.description.abstractEarth-abundant, cheap and non-toxic zinc-based coordination compounds are drawing research attention as promising candidates for various applications, such as photoluminescent materials and anticancer agents. In this paper we report six zinc complexes (1-3-NO3 and 1-3-Cl) with pyridyl-based thiazolyl-hydrazone ligands, which differ in the nature of substituents at the ligands' periphery, anion type, and geometry around the metal ion. The complexes were characterized by single-crystal and powder X-ray diffraction analysis, as well as IR and NMR spectroscopy. The symmetrical complexes 2-Cl and 3-Cl, where zinc atoms are located at a two-fold axis, do not exhibit photophysical properties, unlike their asymmetrical analogs 2-NO3 and 3-NO3 with the same complex cation. Asymmetrical pentacoordinated 1-Cl and hexacoordinated 1-NO3 complexes exhibit photophysical properties. An admixture of allowed intra-ligand (1IL) and chloro (X)-to-ligand charge-transfer (1XLCT) electronic transitions is responsible for the fluorescence of the 1-Cl complex. The origin of the emission of the 1-NO3 complex is ascribed to an admixture of 3IL and ligand-to-ligand charge-transfer (3LLCT) forbidden electronic transitions, while for 3-NO3 most electronic excitations are of LLCT character. The thermal stability of the complexes is in accord with the strength of respective intermolecular interactions. The antiproliferative activity of the complexes was in the nanomolar range on some of the investigated cancer cell lines. Contrary to the increase of antiproliferative activity of the complexes in comparison to the free ligands in cancer cell lines, an acute toxicity determined in the brine shrimp assay follows the opposite trend. The overall results suggest that Zn(ii) thiazoyl-hydrazone complexes have considerable potential as multifunctional materials.sr
dc.language.isoensr
dc.publisherRoyal Society of Chemistrysr
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200116/RS//sr
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200168/RS//sr
dc.relationThe Spanish Government (PGC2018-094503-B-C22, MCIU/AEI/FEDER, UE)sr
dc.relationThe Canary Islands Government (ProID2020010101, ACIISI/FEDER, UE)sr
dc.relationJ. M. L. L. Grant PID2019-104379RB-C22 funded by MCIN/AEI/ 10.13039/501100011033 and by “ERDF A way of making Europe”.sr
dc.relationThe Portuguese Foundation for Science and Technology (FCT) under the scope of the strategic funding UIDP/04378/2020sr
dc.relationThe Portuguese Foundation for Science and Technology (FCT) under the scope of the strategic funding and UIDB/04378/2020.sr
dc.relationFCT by funding 2020.01423.CEECIND/CP1596/CT0003sr
dc.relationThe FCT and FEDER under project 01/SAICT/ 2016 number 022153sr
dc.relationCPCA/A00/7140/2020sr
dc.relationCPCA/A00/7145/2020sr
dc.rightsrestrictedAccesssr
dc.sourceCrystEngCommsr
dc.subjectZn(II) complexessr
dc.subjectthiazolyl-hydrazonessr
dc.subjectanticancer activitysr
dc.titleZn(ii) complexes with thiazolyl-hydrazones: structure, intermolecular interactions, photophysical properties, computational study and anticancer activitysr
dc.typearticlesr
dc.rights.licenseARRsr
dc.citation.volume24
dc.citation.issue29
dc.citation.spage5194
dc.citation.epage5214
dc.citation.rankM21~
dc.identifier.doi10.1039/d2ce00443g
dc.identifier.scopus2-s2.0-85132527018
dc.identifier.wos000813632500001
dc.type.versionpublishedVersionsr


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