Antimalarial peroxides: The first intramolecular 1,2,4,5-tetraoxane
Antimalarijski peroksidi - prvi intramolekulski 1,2,4,5-tetraoksan
Апстракт
An intramolecular steroidal 1,2,4,5-tetraoxane has been synthesised in six steps starting from methyl3-oxo-7α,12α-diacetoxy-5β-cholan-24-oate. The synthesised 1,2,4,5-tetraoxane has moderate in vitro antimalarial activity against P. falciparum strains (IC50 (D6) = 0.35 µg/mL; IC50 (W2) = 0.29 µg/mL).
Polazeći od methyl 3-oxo-7α,12α-diacetoxy-5β-cholan-24-oate sintetisan je u šest faza intramolekulski steroidni 1,2,4,5-tetraoksan. Proizvod ima umerenu in vitro antimalarijsku aktivnost prema P. falciparum sojevima (IC50 (D6) = 0.35 µg/mL; IC50 (W2) = 0.29 µg/mL).
Кључне речи:
tetraoxane / malaria / peroxide / steroid / intramolecularИзвор:
Journal of the Serbian Chemical Society, 2002, 67, 7, 465-471Издавач:
- Serbian Chemical Society
DOI: 10.2298/JSC0207465O
ISSN: 0352-5139
WoS: 000177384000001
Scopus: 2-s2.0-0036377759
Институција/група
IHTMTY - JOUR AU - Opsenica, Dejan AU - Pocsfalvi, Gabriella AU - Milhous, Wilbur K. AU - Šolaja, Bogdan PY - 2002 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/53 AB - An intramolecular steroidal 1,2,4,5-tetraoxane has been synthesised in six steps starting from methyl3-oxo-7α,12α-diacetoxy-5β-cholan-24-oate. The synthesised 1,2,4,5-tetraoxane has moderate in vitro antimalarial activity against P. falciparum strains (IC50 (D6) = 0.35 µg/mL; IC50 (W2) = 0.29 µg/mL). AB - Polazeći od methyl 3-oxo-7α,12α-diacetoxy-5β-cholan-24-oate sintetisan je u šest faza intramolekulski steroidni 1,2,4,5-tetraoksan. Proizvod ima umerenu in vitro antimalarijsku aktivnost prema P. falciparum sojevima (IC50 (D6) = 0.35 µg/mL; IC50 (W2) = 0.29 µg/mL). PB - Serbian Chemical Society T2 - Journal of the Serbian Chemical Society T1 - Antimalarial peroxides: The first intramolecular 1,2,4,5-tetraoxane T1 - Antimalarijski peroksidi - prvi intramolekulski 1,2,4,5-tetraoksan VL - 67 IS - 7 SP - 465 EP - 471 DO - 10.2298/JSC0207465O ER -
@article{ author = "Opsenica, Dejan and Pocsfalvi, Gabriella and Milhous, Wilbur K. and Šolaja, Bogdan", year = "2002", abstract = "An intramolecular steroidal 1,2,4,5-tetraoxane has been synthesised in six steps starting from methyl3-oxo-7α,12α-diacetoxy-5β-cholan-24-oate. The synthesised 1,2,4,5-tetraoxane has moderate in vitro antimalarial activity against P. falciparum strains (IC50 (D6) = 0.35 µg/mL; IC50 (W2) = 0.29 µg/mL)., Polazeći od methyl 3-oxo-7α,12α-diacetoxy-5β-cholan-24-oate sintetisan je u šest faza intramolekulski steroidni 1,2,4,5-tetraoksan. Proizvod ima umerenu in vitro antimalarijsku aktivnost prema P. falciparum sojevima (IC50 (D6) = 0.35 µg/mL; IC50 (W2) = 0.29 µg/mL).", publisher = "Serbian Chemical Society", journal = "Journal of the Serbian Chemical Society", title = "Antimalarial peroxides: The first intramolecular 1,2,4,5-tetraoxane, Antimalarijski peroksidi - prvi intramolekulski 1,2,4,5-tetraoksan", volume = "67", number = "7", pages = "465-471", doi = "10.2298/JSC0207465O" }
Opsenica, D., Pocsfalvi, G., Milhous, W. K.,& Šolaja, B.. (2002). Antimalarial peroxides: The first intramolecular 1,2,4,5-tetraoxane. in Journal of the Serbian Chemical Society Serbian Chemical Society., 67(7), 465-471. https://doi.org/10.2298/JSC0207465O
Opsenica D, Pocsfalvi G, Milhous WK, Šolaja B. Antimalarial peroxides: The first intramolecular 1,2,4,5-tetraoxane. in Journal of the Serbian Chemical Society. 2002;67(7):465-471. doi:10.2298/JSC0207465O .
Opsenica, Dejan, Pocsfalvi, Gabriella, Milhous, Wilbur K., Šolaja, Bogdan, "Antimalarial peroxides: The first intramolecular 1,2,4,5-tetraoxane" in Journal of the Serbian Chemical Society, 67, no. 7 (2002):465-471, https://doi.org/10.2298/JSC0207465O . .