Приказ основних података о документу

dc.creatorFilipović, Vuk
dc.creatorBabić Radić, Marija M.
dc.creatorVuković, Jovana S.
dc.creatorVukomanović, Marija
dc.creatorRubert, Marina
dc.creatorHofmann, Sandra
dc.creatorMüller, Ralph
dc.creatorTomić, Simonida Lj.
dc.date.accessioned2022-09-26T12:24:20Z
dc.date.available2022-09-26T12:24:20Z
dc.date.issued2022
dc.identifier.issn2073-4360
dc.identifier.urihttps://cer.ihtm.bg.ac.rs/handle/123456789/5309
dc.description.abstractNew composite 3D scaffolds were developed as a combination of synthetic polymer, poly(2- hydroxyethyl methacrylate) (PHEMA), and a natural polymer, gelatin, with a ceramic component, nanohydroxyapatite (ID nHAp) dopped with metal ions. The combination of a synthetic polymer, to be able to tune the structure and the physicochemical and mechanical properties, and a natural polymer, to ensure the specific biological functions of the scaffold, with inorganic filler was applied. The goal was to make a new material with superior properties for applications in the biomedical field which mimics as closely as possible the native bone extracellular matrix (ECM). Biodegrad able PHEMA hydrogel was obtained by crosslinking HEMA by poly(β-amino esters) (PBAE). The scaffold’s physicochemical and mechanical properties, in vitro degradation, and biological activity were assessed so to study the effects of the incorporation of nHAp in the (PHEMA/PBAE/gelatin) hydrogel, as well as the effect of the different pore-forming methods. Cryogels had higher elasticity, swelling, porosity, and percent of mass loss during degradation than the samples obtained by poro genation. The composite scaffolds had a higher mechanical strength, 10.14 MPa for the porogenated samples and 5.87 MPa for the cryogels, but a slightly lower degree of swelling, percent of mass loss, and porosity than the hybrid ones. All the scaffolds were nontoxic and had a high cell adhesion rate, which was 15–20% higher in the composite samples. Cell metabolic activity after 2 and 7 days of culture was higher in the composites, although not statistically different. After 28 days, cell metabolic activity was similar in all scaffolds and the TCP control. No effect of integrating nHAp into the scaffolds on osteogenic cell differentiation could be observed. Synergetic effects occurred which influenced the mechanical behavior, structure, physicochemical properties, and interactions with biological species.sr
dc.language.isoensr
dc.publisherMDPIsr
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172026/RS//sr
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172062/RS//sr
dc.relationSCOPES program of the Swiss National Science Foundation (SNSF) and the Swiss Agency for Development and Cooperation (SDC) (grants No. IZ73ZO_152327)sr
dc.rightsopenAccesssr
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourcePolymerssr
dc.subject2-hydroxyethyl methacrylatesr
dc.subjectPBAEsr
dc.subjectgelatinsr
dc.subjectdopped hydroxyapatitesr
dc.subjectBiocompatibilitysr
dc.subjectBiodegradable scaffoldssr
dc.subjectHydrogel scaffolding biomaterialsr
dc.subjectTissue regeneration engineeringsr
dc.subjectbiokompatibilnostsr
dc.titleBiodegradable Hydrogel Scaffolds Based on 2-Hydroxyethyl Methacrylate, Gelatin, Poly(β-amino esters), and Hydroxyapatitesr
dc.typearticlesr
dc.rights.licenseBYsr
dc.citation.volume14
dc.citation.issue1
dc.citation.spage18
dc.citation.rankM21~
dc.identifier.pmid35012041
dc.identifier.doi10.3390/polym14010018
dc.identifier.fulltexthttp://cer.ihtm.bg.ac.rs/bitstream/id/22588/polymers-14-00018-v3.pdf
dc.identifier.scopus2-s2.0-85121803851
dc.identifier.wos000751013700001
dc.type.versionpublishedVersionsr


Документи

Thumbnail

Овај документ се појављује у следећим колекцијама

Приказ основних података о документу