Antimalarial peroxides: The first intramolecular 1,2,4,5-tetraoxane
Antimalarijski peroksidi - prvi intramolekulski 1,2,4,5-tetraoksan
Abstract
An intramolecular steroidal 1,2,4,5-tetraoxane has been synthesised in six steps starting from methyl3-oxo-7α,12α-diacetoxy-5β-cholan-24-oate. The synthesised 1,2,4,5-tetraoxane has moderate in vitro antimalarial activity against P. falciparum strains (IC50 (D6) = 0.35 µg/mL; IC50 (W2) = 0.29 µg/mL).
Polazeći od methyl 3-oxo-7α,12α-diacetoxy-5β-cholan-24-oate sintetisan je u šest faza intramolekulski steroidni 1,2,4,5-tetraoksan. Proizvod ima umerenu in vitro antimalarijsku aktivnost prema P. falciparum sojevima (IC50 (D6) = 0.35 µg/mL; IC50 (W2) = 0.29 µg/mL).
Keywords:
tetraoxane / malaria / peroxide / steroid / intramolecularSource:
Journal of the Serbian Chemical Society, 2002, 67, 7, 465-471Publisher:
- Serbian Chemical Society
DOI: 10.2298/JSC0207465O
ISSN: 0352-5139