An intramolecular steroidal 1,2,4,5-tetraoxane has been synthesised in six steps starting from methyl3-oxo-7α,12α-diacetoxy-5β-cholan-24-oate. The synthesised 1,2,4,5-tetraoxane has moderate in vitro antimalarial activity against P. falciparum strains (IC50 (D6) = 0.35 µg/mL; IC50 (W2) = 0.29 µg/mL).
Polazeći od methyl 3-oxo-7α,12α-diacetoxy-5β-cholan-24-oate sintetisan je u šest faza intramolekulski steroidni 1,2,4,5-tetraoksan. Proizvod ima umerenu in vitro antimalarijsku aktivnost prema P. falciparum sojevima (IC50 (D6) = 0.35 µg/mL; IC50 (W2) = 0.29 µg/mL).
TY - JOUR
AU - Opsenica, Dejan
AU - Pocsfalvi, Gabriella
AU - Milhous, Wilbur K.
AU - Šolaja, Bogdan
PY - 2002
UR - http://cer.ihtm.bg.ac.rs/handle/123456789/53
AB - An intramolecular steroidal 1,2,4,5-tetraoxane has been synthesised in six steps starting from methyl3-oxo-7α,12α-diacetoxy-5β-cholan-24-oate. The synthesised 1,2,4,5-tetraoxane has moderate in vitro antimalarial activity against P. falciparum strains (IC50 (D6) = 0.35 µg/mL; IC50 (W2) = 0.29 µg/mL).
AB - Polazeći od methyl 3-oxo-7α,12α-diacetoxy-5β-cholan-24-oate sintetisan je u šest faza intramolekulski steroidni 1,2,4,5-tetraoksan. Proizvod ima umerenu in vitro antimalarijsku aktivnost prema P. falciparum sojevima (IC50 (D6) = 0.35 µg/mL; IC50 (W2) = 0.29 µg/mL).
PB - Serbian Chemical Society
T2 - Journal of the Serbian Chemical Society
T1 - Antimalarial peroxides: The first intramolecular 1,2,4,5-tetraoxane
T1 - Antimalarijski peroksidi - prvi intramolekulski 1,2,4,5-tetraoksan
VL - 67
IS - 7
SP - 465
EP - 471
DO - 10.2298/JSC0207465O
ER -
@article{
author = "Opsenica, Dejan and Pocsfalvi, Gabriella and Milhous, Wilbur K. and Šolaja, Bogdan",
year = "2002",
url = "http://cer.ihtm.bg.ac.rs/handle/123456789/53",
abstract = "An intramolecular steroidal 1,2,4,5-tetraoxane has been synthesised in six steps starting from methyl3-oxo-7α,12α-diacetoxy-5β-cholan-24-oate. The synthesised 1,2,4,5-tetraoxane has moderate in vitro antimalarial activity against P. falciparum strains (IC50 (D6) = 0.35 µg/mL; IC50 (W2) = 0.29 µg/mL)., Polazeći od methyl 3-oxo-7α,12α-diacetoxy-5β-cholan-24-oate sintetisan je u šest faza intramolekulski steroidni 1,2,4,5-tetraoksan. Proizvod ima umerenu in vitro antimalarijsku aktivnost prema P. falciparum sojevima (IC50 (D6) = 0.35 µg/mL; IC50 (W2) = 0.29 µg/mL).",
publisher = "Serbian Chemical Society",
journal = "Journal of the Serbian Chemical Society",
title = "Antimalarial peroxides: The first intramolecular 1,2,4,5-tetraoxane, Antimalarijski peroksidi - prvi intramolekulski 1,2,4,5-tetraoksan",
volume = "67",
number = "7",
pages = "465-471",
doi = "10.2298/JSC0207465O"
}
Opsenica D, Pocsfalvi G, Milhous WK, Šolaja B. Antimalarijski peroksidi - prvi intramolekulski 1,2,4,5-tetraoksan. Journal of the Serbian Chemical Society. 2002;67(7):465-471
Opsenica, D., Pocsfalvi, G., Milhous, W. K.,& Šolaja, B. (2002). Antimalarijski peroksidi - prvi intramolekulski 1,2,4,5-tetraoksan.
Journal of the Serbian Chemical SocietySerbian Chemical Society., 67(7), 465-471.
https://doi.org/10.2298/JSC0207465O
