Biobased thermo/pH sensitive poly(N-isopropylacrylamide-co-crotonic acid) hydrogels for targeted drug delivery
Само за регистроване кориснике
2022
Аутори
Marković, Maja D.Panić, Vesna
Savić, Sanja I.
Ugrinović, Vukašin
Pjanović, Rada
Spasojević, Milica
Spasojević, Pavle
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Materials sensitive to external stimuli are recognized as safe and effective tool able to respond to specific demands in the therapy of various diseases. Thermo sensitive hydrogels based on poly(N-isopropylacrylamide) (P(NIPAAM)) are widely investigated for targeted drug delivery. Still, the abundance of the stimuli in the human body often requires more than one responsive group able to act simultaneously to achieve optimal therapeutic effects. Due to its pH sensitivity and bio-based production, crotonic acid (CA) was a monomer of choice for preparation of eco-friendly copolymer hydrogels based on NIPAAM and CA (P(NIPAAMcoCA)), which turned to be thermo and pH sensitive at the same time. The potential of the P(NIPAAMcoCA) system for encapsulation and controlled release of drugs with different solubility was investigated engaging water-soluble lidocaine hydrochloride and poorly water-soluble ibuprofen as model drugs. The hydrogels were characterized by various technics: FTIR, DSC, SEM a...nd single compressive tests, while swelling behavior and controlled release of the drugs were analyzed with respect to the CA amount in two environments with different pH values at 25 °C and 37 °C. It was demonstrated that due to their dual responsiveness the P(NIPAAMcoCA) hydrogels have potential for controlled release of drugs with different solubility.
Кључне речи:
Crotonic acid / Dual responsive hydrogels / Poly(N-isopropylacrylamide) / Sustainable materials / Targeted drug delivery / Кротонска киселина / Одрживи материјалиИзвор:
Microporous and Mesoporous Materials, 2022, 335, 111817-Издавач:
- Elsevier
Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200043 (Институт за онкологију и радиологију Србије, Београд) (RS-MESTD-inst-2020-200043)
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200287 (Иновациони центар Технолошко-металуршког факултета у Београду доо) (RS-MESTD-inst-2020-200287)
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200288 (Иновациони центар Хемијског факултета у Београду доо) (RS-MESTD-inst-2020-200288)
DOI: 10.1016/j.micromeso.2022.111817
ISSN: 1387-1811; 1873-3093
WoS: 000787887100002
Scopus: 2-s2.0-85126965149
Институција/група
IHTMTY - JOUR AU - Marković, Maja D. AU - Panić, Vesna AU - Savić, Sanja I. AU - Ugrinović, Vukašin AU - Pjanović, Rada AU - Spasojević, Milica AU - Spasojević, Pavle PY - 2022 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/5295 AB - Materials sensitive to external stimuli are recognized as safe and effective tool able to respond to specific demands in the therapy of various diseases. Thermo sensitive hydrogels based on poly(N-isopropylacrylamide) (P(NIPAAM)) are widely investigated for targeted drug delivery. Still, the abundance of the stimuli in the human body often requires more than one responsive group able to act simultaneously to achieve optimal therapeutic effects. Due to its pH sensitivity and bio-based production, crotonic acid (CA) was a monomer of choice for preparation of eco-friendly copolymer hydrogels based on NIPAAM and CA (P(NIPAAMcoCA)), which turned to be thermo and pH sensitive at the same time. The potential of the P(NIPAAMcoCA) system for encapsulation and controlled release of drugs with different solubility was investigated engaging water-soluble lidocaine hydrochloride and poorly water-soluble ibuprofen as model drugs. The hydrogels were characterized by various technics: FTIR, DSC, SEM and single compressive tests, while swelling behavior and controlled release of the drugs were analyzed with respect to the CA amount in two environments with different pH values at 25 °C and 37 °C. It was demonstrated that due to their dual responsiveness the P(NIPAAMcoCA) hydrogels have potential for controlled release of drugs with different solubility. PB - Elsevier T2 - Microporous and Mesoporous Materials T1 - Biobased thermo/pH sensitive poly(N-isopropylacrylamide-co-crotonic acid) hydrogels for targeted drug delivery VL - 335 SP - 111817 DO - 10.1016/j.micromeso.2022.111817 ER -
@article{ author = "Marković, Maja D. and Panić, Vesna and Savić, Sanja I. and Ugrinović, Vukašin and Pjanović, Rada and Spasojević, Milica and Spasojević, Pavle", year = "2022", abstract = "Materials sensitive to external stimuli are recognized as safe and effective tool able to respond to specific demands in the therapy of various diseases. Thermo sensitive hydrogels based on poly(N-isopropylacrylamide) (P(NIPAAM)) are widely investigated for targeted drug delivery. Still, the abundance of the stimuli in the human body often requires more than one responsive group able to act simultaneously to achieve optimal therapeutic effects. Due to its pH sensitivity and bio-based production, crotonic acid (CA) was a monomer of choice for preparation of eco-friendly copolymer hydrogels based on NIPAAM and CA (P(NIPAAMcoCA)), which turned to be thermo and pH sensitive at the same time. The potential of the P(NIPAAMcoCA) system for encapsulation and controlled release of drugs with different solubility was investigated engaging water-soluble lidocaine hydrochloride and poorly water-soluble ibuprofen as model drugs. The hydrogels were characterized by various technics: FTIR, DSC, SEM and single compressive tests, while swelling behavior and controlled release of the drugs were analyzed with respect to the CA amount in two environments with different pH values at 25 °C and 37 °C. It was demonstrated that due to their dual responsiveness the P(NIPAAMcoCA) hydrogels have potential for controlled release of drugs with different solubility.", publisher = "Elsevier", journal = "Microporous and Mesoporous Materials", title = "Biobased thermo/pH sensitive poly(N-isopropylacrylamide-co-crotonic acid) hydrogels for targeted drug delivery", volume = "335", pages = "111817", doi = "10.1016/j.micromeso.2022.111817" }
Marković, M. D., Panić, V., Savić, S. I., Ugrinović, V., Pjanović, R., Spasojević, M.,& Spasojević, P.. (2022). Biobased thermo/pH sensitive poly(N-isopropylacrylamide-co-crotonic acid) hydrogels for targeted drug delivery. in Microporous and Mesoporous Materials Elsevier., 335, 111817. https://doi.org/10.1016/j.micromeso.2022.111817
Marković MD, Panić V, Savić SI, Ugrinović V, Pjanović R, Spasojević M, Spasojević P. Biobased thermo/pH sensitive poly(N-isopropylacrylamide-co-crotonic acid) hydrogels for targeted drug delivery. in Microporous and Mesoporous Materials. 2022;335:111817. doi:10.1016/j.micromeso.2022.111817 .
Marković, Maja D., Panić, Vesna, Savić, Sanja I., Ugrinović, Vukašin, Pjanović, Rada, Spasojević, Milica, Spasojević, Pavle, "Biobased thermo/pH sensitive poly(N-isopropylacrylamide-co-crotonic acid) hydrogels for targeted drug delivery" in Microporous and Mesoporous Materials, 335 (2022):111817, https://doi.org/10.1016/j.micromeso.2022.111817 . .