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dc.creatorSimić, Katarina
dc.creatorTodorović, Nina
dc.creatorTrifunović, Snežana
dc.creatorMiladinović, Zoran P.
dc.creatorGavrilović, Aleksandra
dc.creatorJovanović, Silvana
dc.creatorAvramović, Nataša
dc.creatorGođevac, Dejan
dc.creatorVujisić, Ljubodrag
dc.creatorTešević, Vele
dc.creatorTasić, Ljubica
dc.creatorMandić, Boris
dc.date.accessioned2022-08-10T07:43:23Z
dc.date.available2022-08-10T07:43:23Z
dc.date.issued2022
dc.identifier.issn2218-1989
dc.identifier.urihttps://cer.ihtm.bg.ac.rs/handle/123456789/5199
dc.description.abstractSchizophrenia is a widespread mental disorder that leads to significant functional impairments and premature death. The state of the art indicates gaps in the understanding and diagnosis of this disease, but also the need for personalized and precise approaches to patients through customized medical treatment and reliable monitoring of treatment response. In order to fulfill existing gaps, the establishment of a universal set of disorder biomarkers is a necessary step. Metabolomic investigations of serum samples of Serbian patients with schizophrenia (51) and healthy controls (39), based on NMR analyses associated with chemometrics, led to the identification of 26 metabolites/biomarkers for this disorder. Principal component analysis (PCA) and orthogonal partial least squares discriminant analysis (OPLS-DA) models with prediction accuracies of 0.9718 and higher were accomplished during chemometric analysis. The established biomarker set includes aspartate/aspartic acid, lysine, 2-hydroxybutyric acid, and acylglycerols, which are identified for the first time in schizophrenia serum samples by NMR experiments. The other 22 identified metabolites in the Serbian samples are in accordance with the previously established NMR-based serum biomarker sets of Brazilian and/or Chinese patient samples. Thirteen metabolites (lactate/lactic acid, threonine, leucine, isoleucine, valine, glutamine, asparagine, alanine, gamma-aminobutyric acid, choline, glucose, glycine and tyrosine) that are common for three different ethnic and geographic origins (Serbia, Brazil and China) could be a good start point for the setup of a universal NMR serum biomarker set for schizophrenia.sr
dc.language.isoensr
dc.publisherMDPIsr
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200168/RS//sr
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200026/RS//sr
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200051/RS//sr
dc.relationProhibition of Chemical Weapons - OPCW (Project Account No: L/ICA/ICB-217652/18)sr
dc.relationProhibition of Chemical Weapons - OPCW (Project Account No: L/ICA/ICB-108/21)sr
dc.rightsopenAccesssr
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceMetabolitessr
dc.subjectschizophreniasr
dc.subjectmetabolomicssr
dc.subjectbiomarkerssr
dc.subjectNMRsr
dc.subjectchemometricssr
dc.subjectserum metabolitessr
dc.titleNMR Metabolomics in Serum Fingerprinting of Schizophrenia Patients in a Serbian Cohortsr
dc.typearticlesr
dc.rights.licenseBYsr
dc.citation.volume12
dc.citation.issue8
dc.citation.spage707
dc.citation.rankM22~
dc.identifier.doi10.3390/metabo12080707
dc.identifier.fulltexthttp://cer.ihtm.bg.ac.rs/bitstream/id/22259/metabolites-12-00707-v2.pdf
dc.identifier.wos00084547830000
dc.type.versionpublishedVersionsr


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