Proučavanje ravnoteža u heterogenim sistemima tricikličnog antidepresiva amitriptilina
Study of equilibria in heterogeneous systems of tricyclic antidepressant amitriptyline
Konferencijski prilog (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Cilj ovog rada bio je proučavanje ravnoteža u heterogenim sistemima tricikličnog
antidepresiva amitriptilina (Am) koji sadrže hloride i/ili fosfate. Rastvorljivost Am u
uslovima povećane jonske sile određena je pH–Ramp shake–flask metodom. Veća
rastvorljivost Am u kiseloj sredini od očekivane, posledica je agregacije – analiza
eksperimentalnih podataka pomoću programa pDISOL–XTM ukazuje na verovatno
građenje pentamera Am5H5 5+. Kritična micelarna koncentracija i stepen disocijacije
agregata određeni su primenom konduktometrijskih titracija. U baznoj sredini primećena je
delimična degradacija Am. Eksperimentalno dobijeni podaci o rastvorljivosti biološki
aktivnih supstanci i postojećim ravnotežama u heterogenim sistemima važni su u svim
fazama dizajna i razvoja lekova.
The aim of this work was to study the equilibria in tricyclic antidepressant amitriptyline
(Am) heterogeneous systems containing chloride and/or phosphate ions. Solubility of Am
in high ionic strength conditions was determined using pH–Ramp shake–flask method.1, 2
Higher solubility of Am than expected in an acidic media is a consequence of self-aggregation – pentamer formation (Am5H5 5+) according to pDISOL–XTM analysis. Critical
micelle concentration and the degree of the aggregate dissociation were determined by
conductometric titrations. Partial degradation of Am in alkaline suspensions was observed.
Experimental studies of solubility as well as the existing equilibria in heterogeneous
systems of biologically active compounds are important at all stages of drug design and
development.
Ključne reči:
chemical equilibrium / pH–Ramp shake–flask method / amitriptyline / solubilityIzvor:
Book of Abstracts, Proceedings - 58th Meeting of the Serbian Chemical Society, Belgrade, Serbia, June 9-10, 2022 / Kratki izvodi radova, kjniga radova - 58. Savetovanje Srpskog hemijskog društva, Beograd 9. i 10. jun 2022. godine, 2022, 53-53Izdavač:
- Belgrade : Serbian Chemical Society
Finansiranje / projekti:
- Ministarstvo nauke, tehnološkog razvoja i inovacija Republike Srbije, institucionalno finansiranje - 200026 (Univerzitet u Beogradu, Institut za hemiju, tehnologiju i metalurgiju - IHTM) (RS-MESTD-inst-2020-200026)
- Ministarstvo nauke, tehnološkog razvoja i inovacija Republike Srbije, institucionalno finansiranje - 200288 (Inovacioni centar Hemijskog fakulteta u Beogradu doo) (RS-MESTD-inst-2020-200288)
Institucija/grupa
IHTMTY - CONF AU - Marković, Olivera AU - Gajić, Brankica P. AU - Pešić, Miloš P. AU - Verbić, Tatjana Ž. PY - 2022 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/5087 AB - Cilj ovog rada bio je proučavanje ravnoteža u heterogenim sistemima tricikličnog antidepresiva amitriptilina (Am) koji sadrže hloride i/ili fosfate. Rastvorljivost Am u uslovima povećane jonske sile određena je pH–Ramp shake–flask metodom. Veća rastvorljivost Am u kiseloj sredini od očekivane, posledica je agregacije – analiza eksperimentalnih podataka pomoću programa pDISOL–XTM ukazuje na verovatno građenje pentamera Am5H5 5+. Kritična micelarna koncentracija i stepen disocijacije agregata određeni su primenom konduktometrijskih titracija. U baznoj sredini primećena je delimična degradacija Am. Eksperimentalno dobijeni podaci o rastvorljivosti biološki aktivnih supstanci i postojećim ravnotežama u heterogenim sistemima važni su u svim fazama dizajna i razvoja lekova. AB - The aim of this work was to study the equilibria in tricyclic antidepressant amitriptyline (Am) heterogeneous systems containing chloride and/or phosphate ions. Solubility of Am in high ionic strength conditions was determined using pH–Ramp shake–flask method.1, 2 Higher solubility of Am than expected in an acidic media is a consequence of self-aggregation – pentamer formation (Am5H5 5+) according to pDISOL–XTM analysis. Critical micelle concentration and the degree of the aggregate dissociation were determined by conductometric titrations. Partial degradation of Am in alkaline suspensions was observed. Experimental studies of solubility as well as the existing equilibria in heterogeneous systems of biologically active compounds are important at all stages of drug design and development. PB - Belgrade : Serbian Chemical Society C3 - Book of Abstracts, Proceedings - 58th Meeting of the Serbian Chemical Society, Belgrade, Serbia, June 9-10, 2022 / Kratki izvodi radova, kjniga radova - 58. Savetovanje Srpskog hemijskog društva, Beograd 9. i 10. jun 2022. godine T1 - Proučavanje ravnoteža u heterogenim sistemima tricikličnog antidepresiva amitriptilina T1 - Study of equilibria in heterogeneous systems of tricyclic antidepressant amitriptyline SP - 53 EP - 53 UR - https://hdl.handle.net/21.15107/rcub_cer_5087 ER -
@conference{ author = "Marković, Olivera and Gajić, Brankica P. and Pešić, Miloš P. and Verbić, Tatjana Ž.", year = "2022", abstract = "Cilj ovog rada bio je proučavanje ravnoteža u heterogenim sistemima tricikličnog antidepresiva amitriptilina (Am) koji sadrže hloride i/ili fosfate. Rastvorljivost Am u uslovima povećane jonske sile određena je pH–Ramp shake–flask metodom. Veća rastvorljivost Am u kiseloj sredini od očekivane, posledica je agregacije – analiza eksperimentalnih podataka pomoću programa pDISOL–XTM ukazuje na verovatno građenje pentamera Am5H5 5+. Kritična micelarna koncentracija i stepen disocijacije agregata određeni su primenom konduktometrijskih titracija. U baznoj sredini primećena je delimična degradacija Am. Eksperimentalno dobijeni podaci o rastvorljivosti biološki aktivnih supstanci i postojećim ravnotežama u heterogenim sistemima važni su u svim fazama dizajna i razvoja lekova., The aim of this work was to study the equilibria in tricyclic antidepressant amitriptyline (Am) heterogeneous systems containing chloride and/or phosphate ions. Solubility of Am in high ionic strength conditions was determined using pH–Ramp shake–flask method.1, 2 Higher solubility of Am than expected in an acidic media is a consequence of self-aggregation – pentamer formation (Am5H5 5+) according to pDISOL–XTM analysis. Critical micelle concentration and the degree of the aggregate dissociation were determined by conductometric titrations. Partial degradation of Am in alkaline suspensions was observed. Experimental studies of solubility as well as the existing equilibria in heterogeneous systems of biologically active compounds are important at all stages of drug design and development.", publisher = "Belgrade : Serbian Chemical Society", journal = "Book of Abstracts, Proceedings - 58th Meeting of the Serbian Chemical Society, Belgrade, Serbia, June 9-10, 2022 / Kratki izvodi radova, kjniga radova - 58. Savetovanje Srpskog hemijskog društva, Beograd 9. i 10. jun 2022. godine", title = "Proučavanje ravnoteža u heterogenim sistemima tricikličnog antidepresiva amitriptilina, Study of equilibria in heterogeneous systems of tricyclic antidepressant amitriptyline", pages = "53-53", url = "https://hdl.handle.net/21.15107/rcub_cer_5087" }
Marković, O., Gajić, B. P., Pešić, M. P.,& Verbić, T. Ž.. (2022). Proučavanje ravnoteža u heterogenim sistemima tricikličnog antidepresiva amitriptilina. in Book of Abstracts, Proceedings - 58th Meeting of the Serbian Chemical Society, Belgrade, Serbia, June 9-10, 2022 / Kratki izvodi radova, kjniga radova - 58. Savetovanje Srpskog hemijskog društva, Beograd 9. i 10. jun 2022. godine Belgrade : Serbian Chemical Society., 53-53. https://hdl.handle.net/21.15107/rcub_cer_5087
Marković O, Gajić BP, Pešić MP, Verbić TŽ. Proučavanje ravnoteža u heterogenim sistemima tricikličnog antidepresiva amitriptilina. in Book of Abstracts, Proceedings - 58th Meeting of the Serbian Chemical Society, Belgrade, Serbia, June 9-10, 2022 / Kratki izvodi radova, kjniga radova - 58. Savetovanje Srpskog hemijskog društva, Beograd 9. i 10. jun 2022. godine. 2022;:53-53. https://hdl.handle.net/21.15107/rcub_cer_5087 .
Marković, Olivera, Gajić, Brankica P., Pešić, Miloš P., Verbić, Tatjana Ž., "Proučavanje ravnoteža u heterogenim sistemima tricikličnog antidepresiva amitriptilina" in Book of Abstracts, Proceedings - 58th Meeting of the Serbian Chemical Society, Belgrade, Serbia, June 9-10, 2022 / Kratki izvodi radova, kjniga radova - 58. Savetovanje Srpskog hemijskog društva, Beograd 9. i 10. jun 2022. godine (2022):53-53, https://hdl.handle.net/21.15107/rcub_cer_5087 .