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dc.creatorMarković, Olivera
dc.creatorPatel, Nirali G.
dc.creatorSerajuddin, Abu T. M.
dc.creatorAvdeef, Alex
dc.creatorVerbić, Tatjana
dc.date.accessioned2022-02-08T10:49:54Z
dc.date.available2023-01-20
dc.date.issued2022
dc.identifier.issn1543-8384
dc.identifier.urihttps://cer.ihtm.bg.ac.rs/handle/123456789/4936
dc.description.abstractThe solubility of a model basic drug, nortriptyline (Nor), was investigated as a function of pH in phosphate and/or a chloride-containing aqueous suspension using experimental practices recommended in the previously published “white paper” (Avdeef et al., 2016). The pH-Ramp Shake-Flask (pHRSF) method, introduced in our earlier work (Marković et al.,2019), was applied. An improved and more detailed experimentaldesign of the Nor solubility measurement allowed us to exploit thefull capacity of the pH-RSF method. Complex equilibria in theaqueous phase (cationic and anionic complex formation betweenNor and the phosphate) and solid-phase transformations (Nor freebase, 1:1 Nor hydrochloride salt, 1:1 and 1:2 Nor phosphate salts)were characterized by a detailed analysis of the solubilitymeasurements using the computer program pDISOL-X. The solid phases were characterized by thermogravimetric analysis,differential scanning calorimetry, powder X-ray diffraction, and elemental analyses. The results of the present investigation illustratethe influence of competing counterions, such as buffering agents, complexing agents, salt coformers, tonicity adjusters, and so forth,on the aqueous solubility of drugs and interconversion of salts. Careful attention given to these factors can be helpful in theformulation of drug products.sr
dc.language.isoensr
dc.publisherAmerican Chemical Society (ACS)sr
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200026/RS//sr
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200168/RS//sr
dc.relation.isversionofhttps://cer.ihtm.bg.ac.rs/handle/123456789/4934
dc.relation.isversionofhttps://doi.org/10.1021/acs.molpharmaceut.1c00919
dc.relation.isreferencedbyhttps://cer.ihtm.bg.ac.rs/handle/123456789/4935
dc.rightsembargoedAccesssr
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/
dc.sourceMolecular Pharmaceuticssr
dc.subjectnortriptylinesr
dc.subjectnortriptyline hydrochloridesr
dc.subjectphosphate saltssr
dc.subjectcomplexessr
dc.subjectsolubilitysr
dc.subjectsolubility productsr
dc.subjectpH and buffer effectsr
dc.titleNortriptyline Hydrochloride Solubility-pH Profiles in a Saline Phosphate Buffer: Drug-Phosphate Complexes and Multiple pHmax Domains with a Gibbs Phase Rule “Soft” Constraintssr
dc.typearticlesr
dc.rights.licenseBY-NCsr
dc.citation.volume19
dc.citation.issue2
dc.citation.spage710
dc.citation.epage719
dc.citation.rankM21~
dc.description.otherThis is the peer-reviewed version of the article: Marković, Olivera S., Patel, Nirali G., Serajuddin, Abu T. M., Avdeef, Alex, Verbić, Tatjana Ž., "Nortriptyline Hydrochloride Solubility-pH Profiles in a Saline Phosphate Buffer: Drug-Phosphate Complexes and Multiple pHmax Domains with a Gibbs Phase Rule “Soft” Constraints", Molecular Pharmaceutics, 19, no. 2 (2022):710-719, [https://doi.org/10.1021/acs.molpharmaceut.1c00919]
dc.description.otherThis document is the Accepted Manuscript version of a Published Work that appeared in final form in Molecular Pharmaceutics, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see [https://doi.org/10.1021/acs.molpharmaceut.1c00919]
dc.description.otherThe published version: [https://cer.ihtm.bg.ac.rs/handle/123456789/4934]
dc.description.otherSupporting information: [https://cer.ihtm.bg.ac.rs/handle/123456789/4935]
dc.identifier.pmid35050628
dc.identifier.doi10.1021/acs.molpharmaceut.1c00919
dc.identifier.fulltexthttp://cer.ihtm.bg.ac.rs/bitstream/id/21366/acc-post-combined.pdf
dc.identifier.wos000746418500001
dc.type.versionacceptedVersionsr


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