Supporting information for: "Nortriptyline Hydrochloride Solubility-pH Profiles in a Saline Phosphate Buffer: Drug-Phosphate Complexes and Multiple pHmax Domains with a Gibbs Phase Rule “Soft” Constraints"
Abstract
Additional experimental details; preparation of stock suspensions for low-to-high pH and high-to-low pH titrations; titration and solubility data for titration sets 1–11; elemental analysis data from titration sets 9, 3, 6, and 7; and HPLC UV/VIS analysis─sample chromatograms and calibration diagram
Keywords:
nortriptyline / nortriptyline hydrochloride / phosphate salts / complexes / solubility / solubility product / pH and buffer effectSource:
Molecular Pharmaceutics, 2022Publisher:
- American Chemical Society (ACS)
Funding / projects:
- Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 200026 (University of Belgrade, Institute of Chemistry, Technology and Metallurgy - IChTM) (RS-200026)
- Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 200168 (University of Belgrade, Faculty of Chemistry) (RS-200168)
Note:
- The supporting information for: Marković OS, Patel NG, Serajuddin ATM, Avdeef A, Verbić TŽ. Nortriptyline Hydrochloride Solubility-pH Profiles in a Saline Phosphate Buffer: Drug-Phosphate Complexes and Multiple pHmax Domains with a Gibbs Phase Rule “Soft” Constraints. in Molecular Pharmaceutics. 2022;19(2):710-719. doi: 10.1021/acs.molpharmaceut.1c00919
- Published manuscript: https://cer.ihtm.bg.ac.rs/handle/123456789/4934
- The peer-reviewed version: https://cer.ihtm.bg.ac.rs/handle/123456789/4936
Related info:
- Referenced by
https://cer.ihtm.bg.ac.rs/handle/123456789/4934 - Referenced by
https://cer.ihtm.bg.ac.rs/handle/123456789/4936