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Flavonoids of the Heartwood of Cotinus coggygria Scop. Showing Protective Effect on Human Lymphocyte DNA
dc.creator | Milosavljević, Slobodan | |
dc.creator | Đorđević, Iris | |
dc.creator | Mandić, Boris | |
dc.creator | Tešević, Vele | |
dc.creator | Stanković, Miroslava | |
dc.creator | Todorović, Nina | |
dc.creator | Novaković, Miroslav | |
dc.date.accessioned | 2021-12-28T22:54:55Z | |
dc.date.available | 2021-12-28T22:54:55Z | |
dc.date.issued | 2021 | |
dc.identifier.issn | 1934-578X | |
dc.identifier.issn | 1555-9475 | |
dc.identifier.uri | https://cer.ihtm.bg.ac.rs/handle/123456789/4913 | |
dc.description.abstract | In continuation of our study on Cotinus coggygria from Serbia, 10 known flavonoids (1-10) were isolated from the methylene chloride/ methanol extract of the heartwood. They were tested for in vitro protective effect against chromosome aberrations in peripheral human lymphocytes, using the cytokinesis-block micronucleus assay. All tested compounds (in minimal doses of 1 μg/mL) exerted a beneficial effect by decreasing DNA damage of human lymphocytes in the range of 24.2% to 54.5%, better than the radio protectant control, amifostine. Functional groups, such as 3′,4′-dihydroxyphenyl (catechol), 5-OH, 3-OH, and 4-keto in flavonoids (3-keto in aurones), which play a key role in antioxidant activity, are proposed to be responsible for the DNA protective activity of the tested compounds. | |
dc.publisher | SAGE Publications | en |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200026/RS// | en |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200168/RS// | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | |
dc.source | Natural Product Communications | en |
dc.subject | flavonoids | |
dc.subject | Cotinus coggygria Scop. | |
dc.subject | DNA protective activity | |
dc.subject | cytokinesis-block micronucleus assay | |
dc.title | Flavonoids of the Heartwood of Cotinus coggygria Scop. Showing Protective Effect on Human Lymphocyte DNA | en |
dc.type | article | en |
dc.rights.license | BY-NC | |
dc.citation.volume | 16 | |
dc.citation.issue | 12 | |
dc.citation.spage | 1 | |
dc.citation.epage | 8 | |
dc.citation.rank | M23~ | |
dc.identifier.doi | 10.1177/1934578X211067289 | |
dc.identifier.fulltext | http://cer.ihtm.bg.ac.rs/bitstream/id/21284/1934578x211067289.pdf | |
dc.identifier.wos | 000735775300001 | |
dc.type.version | publishedVersion |