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dc.creatorIvković, Ivana
dc.creatorBukvicki, Danka
dc.creatorNovaković, Miroslav
dc.creatorMajstorović, Ivana
dc.creatorLeskovac, Andreja
dc.creatorPetrović, Sandra
dc.creatorVeljić, Milan
dc.date.accessioned2021-12-14T15:47:42Z
dc.date.available2021-12-14T15:47:42Z
dc.date.issued2021
dc.identifier.issn1934-578X
dc.identifier.issn1555-9475
dc.identifier.urihttps://cer.ihtm.bg.ac.rs/handle/123456789/4894
dc.description.abstractLiverworts are characterized by a high content of bioactive compounds reported to show antimicrobial, anticancer, and antioxidant properties. In this study, the biological effects of the methanol extract of the liverwort Pellia endiviifolia and its constituents, bis-bibenzyls perrottetin E, 10′-hydroxyperrottetin E, and 10,10′-dihydroxyperrottetin E, were investigated using human peripheral blood cells as a model system. The assessment of the investigated compounds comprised testing their genotoxicity, apoptotic potential, and redox modulating activities. The genotoxicity testing indicated that medium (25 µM) and high concentrations (100 µM) of the investigated compounds displayed genotoxic and antiproliferative effects in human lymphocytes as revealed by significant, concentration-dependent enhancement of the micronuclei incidence and decrease in the cytokinesis-block proliferation index compared to the control (P <.001). Analysis of leukocyte apoptosis showed a substantial potential of all investigated compounds to induce apoptosis, which was not concentration-dependent. The P endiviifolia extract and perrottetin E demonstrated considerable pro-apoptotic potential, even at the lowest concentration (1 µM) applied. Evaluation of the redox modulating effects, which comprised measuring erythrocyte catalase activity and the lymphocyte malondialdehyde level, showed that the investigated compounds did not induce oxidative stress in human peripheral blood cells (P >.05). The observed genotoxic, antiproliferative, and proapoptotic effects of the investigated compounds make them suitable for further comprehensive studies related to their possible applications as anticancer agents.sr
dc.language.isoensr
dc.publisherSAGE Publications Inc.sr
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200017/RS//sr
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200026/RS//sr
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200178/RS//sr
dc.rightsopenAccesssr
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/
dc.sourceNatural Product Communicationssr
dc.subject10,10′-dihydroxyperrottetin Esr
dc.subject10′-hydroxyperrottetin Esr
dc.subjectapoptosissr
dc.subjectcatalase activitysr
dc.subjectmalondialdehydesr
dc.subjectmicronucleisr
dc.subjectperrottetin Esr
dc.titleAssessment of the Biological Effects of Pellia endiviifolia and its Constituents in Vitrosr
dc.typearticlesr
dc.rights.licenseBY-NCsr
dc.citation.volume16
dc.citation.issue11
dc.citation.spage1
dc.citation.epage9
dc.citation.rankM23~
dc.identifier.doi10.1177/1934578X211056422
dc.identifier.fulltexthttp://cer.ihtm.bg.ac.rs/bitstream/id/21229/1934578x211056422.pdf
dc.identifier.scopus2-s2.0-85119504636
dc.identifier.wos000721670900001
dc.type.versionpublishedVersionsr


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