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dc.creatorMudrić, Jelena
dc.creatorŠavikin, Katarina
dc.creatorĐekić, Ljiljana
dc.creatorPavlović, Stefan
dc.creatorKurćubić, Ivana
dc.creatorIbrić, Svetlana
dc.creatorĐuriš, Jelena
dc.date.accessioned2021-12-07T15:21:28Z
dc.date.available2021-12-07T15:21:28Z
dc.date.issued2021
dc.identifier.issn1999-4923
dc.identifier.urihttps://cer.ihtm.bg.ac.rs/handle/123456789/4891
dc.description.abstractGentian (Gentiana lutea L., Gentianaceae) root extract (GRE) is used for the treatment of gastrointestinal disorders. However, its bioactive potential is limited in conventional forms due to the low bioavailability and short elimination half-life of the dominant bioactive compound, gentiopicroside. The aim of study was to encapsulate GRE in the lipid-based gastroretentive delivery system that could provide high yield and encapsulation efficiency, as well as the biphasic release of gentiopicroside from the tablets obtained by direct compression. Solid lipid microparticles (SLM) loaded with GRE were prepared by freeze-drying double (W/O/W) emulsions, which were obtained by a multiple emulsion–melt dispersion technique, with GRE as the inner water phase, Gelucire® 39/01 or 43/01, as lipid components, with or without the addition of porous silica (Sylysia® 350) in the outer water phase. Formulated SLM powders were examined by SEM and mercury intrusion porosimetry, as well as by determination of yield, encapsulation efficiency, and flow properties. Furthermore, in vitro dissolution of gentiopicroside, the size of the dispersed systems, mechanical properties, and mucoadhesion of tablets obtained by direct compression were investigated. The results have revealed that SLM with the macroporous structure were formulated, and, consequently, the powders floated immediately in the acidic medium. Formulation with porous silica (Sylysia® 350) and Gelucire® 43/01 as a solid lipid was characterized with the high yield end encapsulation efficiency. Furthermore, the mucoadhesive properties of tablets obtained by direct compression of that formulation, as well as the biphasic release of gentiopicroside, presence of nanoassociates in dissolution medium, and optimal mechanical properties indicated that a promising lipid-based gastroretentive system for GRE was developed.sr
dc.language.isoensr
dc.publisherMDPIsr
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200003/RS//sr
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200161/RS//sr
dc.rightsopenAccesssr
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourcePharmaceuticssr
dc.subjectsolid lipid microparticlessr
dc.subjectSLMsr
dc.subjectgastroretentive systemsr
dc.subjectGelucire 43/01sr
dc.subjectGelucire 39/01sr
dc.subjectSylysia 350sr
dc.subjectgentiopicrosidesr
dc.subjectdouble (W/O/W) emulsionsr
dc.subjectmucoadhesionsr
dc.subjectdirect compressionsr
dc.subjectbiphasic releasesr
dc.titleDevelopment of Lipid-Based Gastroretentive Delivery System for Gentian Extract by Double Emulsion-Melt Dispersion Techniquesr
dc.typearticlesr
dc.rights.licenseBYsr
dc.citation.volume13
dc.citation.issue12
dc.citation.spage2095
dc.citation.rankM21~
dc.identifier.doi10.3390/pharmaceutics13122095
dc.identifier.fulltexthttp://cer.ihtm.bg.ac.rs/bitstream/id/21222/pharmaceutics-13-02095.pdf
dc.identifier.wos000736842000001
dc.type.versionpublishedVersionsr


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