Analysis of Intrinsic Stochastic Fluctuations of the Time Response of Adsorption-Based Microfluidic Bio/Chemical Sensors: the Case of Bianalyte Mixtures
Konferencijski prilog (Recenzirana verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Real-time in situ operation of bio/chemical sensors assumes detection of chemical substances or biological specimens in samples of complex composition. Since sensor selectivity cannot be ideal, adsorption of particles other than target particles inevitably occur on the sensing surface. That affects the sensor response and its intrinsic fluctuations which are caused by stochastic fluctuations of the numbers of adsorbed particles of all the adsorbing substances. In microfluidic sensors, such response fluctuations are a result of coupled adsorption, desorption and mass transfer (convection and diffusion) processes of analyte particles. Analysis of these fluctuations is important because they constitute the adsorption-desorption noise, which limits the sensing performance. In this work we perform the analysis of fluctuations by using a stochastic model of sensor response after the steady state is reached, in the case of two-analyte adsorption, considering mass transfer processes. The resul...ts enable estimation of the ultimate sensing performance of adsorption-based microfluidic bio/chemical sensors of different sensing areas, operating in bianalyte mixture environments.
Ključne reči:
Sensors / Fluctuations / Adsorption / Stochastic processes / Microfluidics / Steady-state / Surface treatmentIzvor:
2019 IEEE 31st International Conference on Microelectronics, MIEL 2019 - Proceedings, 2019, 161-164Izdavač:
- Institute of Electrical and Electronics Engineers (IEEE)
Finansiranje / projekti:
- Mikro, nano-sistemi i senzori za primenu u elektroprivredi, procesnoj industriji i zaštiti životne sredine (RS-MESTD-Technological Development (TD or TR)-32008)
- Serbian Academy of Sciences and Arts, Project F-150
Napomena:
- This is the peer-reviewed version of the article: Jokić, I., Djurić, Z., Radulović, K., Frantlović, M., Krstajić, P.M., 2019. Analysis of Intrinsic Stochastic Fluctuations of the Time Response of Adsorption-Based Microfluidic Bio/Chemical Sensors: the Case of Bianalyte Mixtures, in: 2019 IEEE 31st International Conference on Microelectronics (MIEL), pp. 161–164. https://doi.org/10.1109/MIEL.2019.8889579
- The published version: https://cer.ihtm.bg.ac.rs/handle/123456789/3256
Povezane informacije:
- Druga verzija
https://doi.org/10.1109/MIEL.2019.8889579 - Druga verzija
https://cer.ihtm.bg.ac.rs/handle/123456789/3256
DOI: 10.1109/MIEL.2019.8889579
ISBN: 978-1-7281-3419-2
WoS: 000565455600033
Scopus: 2-s2.0-85075336298
Institucija/grupa
IHTMTY - CONF AU - Jokić, Ivana AU - Đurić, Zoran G. AU - Radulović, Katarina AU - Frantlović, Miloš AU - Krstajić, Predrag PY - 2019 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/4866 AB - Real-time in situ operation of bio/chemical sensors assumes detection of chemical substances or biological specimens in samples of complex composition. Since sensor selectivity cannot be ideal, adsorption of particles other than target particles inevitably occur on the sensing surface. That affects the sensor response and its intrinsic fluctuations which are caused by stochastic fluctuations of the numbers of adsorbed particles of all the adsorbing substances. In microfluidic sensors, such response fluctuations are a result of coupled adsorption, desorption and mass transfer (convection and diffusion) processes of analyte particles. Analysis of these fluctuations is important because they constitute the adsorption-desorption noise, which limits the sensing performance. In this work we perform the analysis of fluctuations by using a stochastic model of sensor response after the steady state is reached, in the case of two-analyte adsorption, considering mass transfer processes. The results enable estimation of the ultimate sensing performance of adsorption-based microfluidic bio/chemical sensors of different sensing areas, operating in bianalyte mixture environments. PB - Institute of Electrical and Electronics Engineers (IEEE) C3 - 2019 IEEE 31st International Conference on Microelectronics, MIEL 2019 - Proceedings T1 - Analysis of Intrinsic Stochastic Fluctuations of the Time Response of Adsorption-Based Microfluidic Bio/Chemical Sensors: the Case of Bianalyte Mixtures SP - 161 EP - 164 DO - 10.1109/MIEL.2019.8889579 ER -
@conference{ author = "Jokić, Ivana and Đurić, Zoran G. and Radulović, Katarina and Frantlović, Miloš and Krstajić, Predrag", year = "2019", abstract = "Real-time in situ operation of bio/chemical sensors assumes detection of chemical substances or biological specimens in samples of complex composition. Since sensor selectivity cannot be ideal, adsorption of particles other than target particles inevitably occur on the sensing surface. That affects the sensor response and its intrinsic fluctuations which are caused by stochastic fluctuations of the numbers of adsorbed particles of all the adsorbing substances. In microfluidic sensors, such response fluctuations are a result of coupled adsorption, desorption and mass transfer (convection and diffusion) processes of analyte particles. Analysis of these fluctuations is important because they constitute the adsorption-desorption noise, which limits the sensing performance. In this work we perform the analysis of fluctuations by using a stochastic model of sensor response after the steady state is reached, in the case of two-analyte adsorption, considering mass transfer processes. The results enable estimation of the ultimate sensing performance of adsorption-based microfluidic bio/chemical sensors of different sensing areas, operating in bianalyte mixture environments.", publisher = "Institute of Electrical and Electronics Engineers (IEEE)", journal = "2019 IEEE 31st International Conference on Microelectronics, MIEL 2019 - Proceedings", title = "Analysis of Intrinsic Stochastic Fluctuations of the Time Response of Adsorption-Based Microfluidic Bio/Chemical Sensors: the Case of Bianalyte Mixtures", pages = "161-164", doi = "10.1109/MIEL.2019.8889579" }
Jokić, I., Đurić, Z. G., Radulović, K., Frantlović, M.,& Krstajić, P.. (2019). Analysis of Intrinsic Stochastic Fluctuations of the Time Response of Adsorption-Based Microfluidic Bio/Chemical Sensors: the Case of Bianalyte Mixtures. in 2019 IEEE 31st International Conference on Microelectronics, MIEL 2019 - Proceedings Institute of Electrical and Electronics Engineers (IEEE)., 161-164. https://doi.org/10.1109/MIEL.2019.8889579
Jokić I, Đurić ZG, Radulović K, Frantlović M, Krstajić P. Analysis of Intrinsic Stochastic Fluctuations of the Time Response of Adsorption-Based Microfluidic Bio/Chemical Sensors: the Case of Bianalyte Mixtures. in 2019 IEEE 31st International Conference on Microelectronics, MIEL 2019 - Proceedings. 2019;:161-164. doi:10.1109/MIEL.2019.8889579 .
Jokić, Ivana, Đurić, Zoran G., Radulović, Katarina, Frantlović, Miloš, Krstajić, Predrag, "Analysis of Intrinsic Stochastic Fluctuations of the Time Response of Adsorption-Based Microfluidic Bio/Chemical Sensors: the Case of Bianalyte Mixtures" in 2019 IEEE 31st International Conference on Microelectronics, MIEL 2019 - Proceedings (2019):161-164, https://doi.org/10.1109/MIEL.2019.8889579 . .