Understanding the Effect of Energy Density and Formulation Factors on the Printability and Characteristics of SLS Irbesartan Tablets-Application of the Decision Tree Model
Authors
Madžarević, MarijanaMedarević, Đorđe
Pavlović, Stefan
Ivković, Branka
Đuriš, Jelena
Ibrić, Svetlana
Article (Published version)
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Selective laser sintering (SLS) is a rapid prototyping technique for the production of three-dimensional objects through selectively sintering powder-based layer materials. The aim of the study was to investigate the effect of energy density (ED) and formulation factors on the printability and characteristics of SLS irbesartan tablets. The correlation between formulation factors, ED, and printability was obtained using a decision tree model with an accuracy of 80%. FT-IR results revealed that there was no interaction between irbesartan and the applied excipients. DSC results indicated that irbesartan was present in an amorphous form in printed tablets. ED had a significant influence on tablets' physical, mechanical, and morphological characteristics. Adding lactose mon-ohydrate enabled faster drug release while reducing the possibility for printing with different laser speeds. However, formulations with crospovidone were printable with a wider range of laser speeds. The adjustment of f...ormulation and process parameters enabled the production of SLS tablets with hydroxypropyl methylcellulose with complete release in less than 30 min. The results suggest that a decision tree could be a useful tool for predicting the printability of pharmaceutical formulations. Tailoring the characteristics of SLS irbesartan tablets by ED is possible; however, it needs to be governed by the composition of the whole formulation.
Keywords:
printability / laser speed / energy density / decision tree / tailoring drug releaseSource:
Pharmaceutics, 2021, 13, 11, 1969-Publisher:
- MDPI
Funding / projects:
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200161 (University of Belgrade, Faculty of Pharmacy) (RS-MESTD-inst-2020-200161)
DOI: 10.3390/pharmaceutics13111969
ISSN: 1999-4923
WoS: 00079296090002
Scopus: 2-s2.0-85120674170
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IHTMTY - JOUR AU - Madžarević, Marijana AU - Medarević, Đorđe AU - Pavlović, Stefan AU - Ivković, Branka AU - Đuriš, Jelena AU - Ibrić, Svetlana PY - 2021 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/4852 AB - Selective laser sintering (SLS) is a rapid prototyping technique for the production of three-dimensional objects through selectively sintering powder-based layer materials. The aim of the study was to investigate the effect of energy density (ED) and formulation factors on the printability and characteristics of SLS irbesartan tablets. The correlation between formulation factors, ED, and printability was obtained using a decision tree model with an accuracy of 80%. FT-IR results revealed that there was no interaction between irbesartan and the applied excipients. DSC results indicated that irbesartan was present in an amorphous form in printed tablets. ED had a significant influence on tablets' physical, mechanical, and morphological characteristics. Adding lactose mon-ohydrate enabled faster drug release while reducing the possibility for printing with different laser speeds. However, formulations with crospovidone were printable with a wider range of laser speeds. The adjustment of formulation and process parameters enabled the production of SLS tablets with hydroxypropyl methylcellulose with complete release in less than 30 min. The results suggest that a decision tree could be a useful tool for predicting the printability of pharmaceutical formulations. Tailoring the characteristics of SLS irbesartan tablets by ED is possible; however, it needs to be governed by the composition of the whole formulation. PB - MDPI T2 - Pharmaceutics T1 - Understanding the Effect of Energy Density and Formulation Factors on the Printability and Characteristics of SLS Irbesartan Tablets-Application of the Decision Tree Model VL - 13 IS - 11 SP - 1969 DO - 10.3390/pharmaceutics13111969 ER -
@article{ author = "Madžarević, Marijana and Medarević, Đorđe and Pavlović, Stefan and Ivković, Branka and Đuriš, Jelena and Ibrić, Svetlana", year = "2021", abstract = "Selective laser sintering (SLS) is a rapid prototyping technique for the production of three-dimensional objects through selectively sintering powder-based layer materials. The aim of the study was to investigate the effect of energy density (ED) and formulation factors on the printability and characteristics of SLS irbesartan tablets. The correlation between formulation factors, ED, and printability was obtained using a decision tree model with an accuracy of 80%. FT-IR results revealed that there was no interaction between irbesartan and the applied excipients. DSC results indicated that irbesartan was present in an amorphous form in printed tablets. ED had a significant influence on tablets' physical, mechanical, and morphological characteristics. Adding lactose mon-ohydrate enabled faster drug release while reducing the possibility for printing with different laser speeds. However, formulations with crospovidone were printable with a wider range of laser speeds. The adjustment of formulation and process parameters enabled the production of SLS tablets with hydroxypropyl methylcellulose with complete release in less than 30 min. The results suggest that a decision tree could be a useful tool for predicting the printability of pharmaceutical formulations. Tailoring the characteristics of SLS irbesartan tablets by ED is possible; however, it needs to be governed by the composition of the whole formulation.", publisher = "MDPI", journal = "Pharmaceutics", title = "Understanding the Effect of Energy Density and Formulation Factors on the Printability and Characteristics of SLS Irbesartan Tablets-Application of the Decision Tree Model", volume = "13", number = "11", pages = "1969", doi = "10.3390/pharmaceutics13111969" }
Madžarević, M., Medarević, Đ., Pavlović, S., Ivković, B., Đuriš, J.,& Ibrić, S.. (2021). Understanding the Effect of Energy Density and Formulation Factors on the Printability and Characteristics of SLS Irbesartan Tablets-Application of the Decision Tree Model. in Pharmaceutics MDPI., 13(11), 1969. https://doi.org/10.3390/pharmaceutics13111969
Madžarević M, Medarević Đ, Pavlović S, Ivković B, Đuriš J, Ibrić S. Understanding the Effect of Energy Density and Formulation Factors on the Printability and Characteristics of SLS Irbesartan Tablets-Application of the Decision Tree Model. in Pharmaceutics. 2021;13(11):1969. doi:10.3390/pharmaceutics13111969 .
Madžarević, Marijana, Medarević, Đorđe, Pavlović, Stefan, Ivković, Branka, Đuriš, Jelena, Ibrić, Svetlana, "Understanding the Effect of Energy Density and Formulation Factors on the Printability and Characteristics of SLS Irbesartan Tablets-Application of the Decision Tree Model" in Pharmaceutics, 13, no. 11 (2021):1969, https://doi.org/10.3390/pharmaceutics13111969 . .