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dc.creatorArsenijević, Dragana
dc.creatorStojanović, Bojana
dc.creatorMilovanović, Jelena
dc.creatorArsenijević, Aleksandar
dc.creatorSimić, Miloš
dc.creatorPergal, Marija
dc.creatorKodranov, Igor
dc.creatorCvetković, Olga
dc.creatorVojvodić, Danilo
dc.creatorRistanović, Elizabeta
dc.creatorManojlović, Dragan
dc.creatorMilovanović, Marija
dc.creatorArsenijević, Nebojša
dc.date.accessioned2021-11-04T20:50:07Z
dc.date.available2021-11-04T20:50:07Z
dc.date.issued2021
dc.identifier.issn2072-6643
dc.identifier.urihttps://cer.ihtm.bg.ac.rs/handle/123456789/4835
dc.description.abstractThe main biologically active components of plants belonging to the genus Allium, responsible for their biological activities, including anti-inflammatory, antioxidant and immunomodulatory, are organosulfur compounds. The aim of this study was to synthetize the mixture of dipropyl polysul-fides (DPPS) and to test their biological activity in acute hepatitis. C57BL/6 mice were administered orally with DPPS 6 h before intravenous injection of Concanavalin A (ConA). Liver inflammation, necrosis and hepatocytes apoptosis were determined by histological analyses. Cytokines in liver tissue were determined by ELISA, expression of adhesive molecules and enzymes by RT PCR, while liver mononuclear cells were analyzed by flow cytometry. DPPS pretreatment significantly attenuated liver inflammation and injury, as evidenced by biochemical and histopathological observations. In DPPS-pretreated mice, messenger RNA levels of adhesion molecules and NADPH oxidase complex were significantly reduced, while the expression of SOD enzymes was enhanced. DPPS pretreatment decreased protein level of inflammatory cytokines and increased percentage of T regulatory cells in the livers of ConA mice. DPPS showed hepatoprotective effects in ConA-induced hepatitis, charac-terized by attenuation of inflammation and affection of Th17/Treg balance in favor of T regulatory cells and implicating potential therapeutic usage of DPPS mixture in inflammatory liver diseases.sr
dc.language.isoensr
dc.publisherMDPIsr
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175069/RS//sr
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200026/RS//sr
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200168/RS//sr
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172018/RS//sr
dc.relationThe Serbian bilateral project with PR China (06/2018)sr
dc.relationThe Faculty of Medical Sciences, University of Kragujevac - MP 01/19sr
dc.relationThe Faculty of Medical Sciences, University of Kragujevac - JP 22/19sr
dc.rightsopenAccesssr
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceNutrientssr
dc.subjectAnti-inflammatory activitysr
dc.subjectConA hepatitissr
dc.subjectDipropyl polysulfidessr
dc.subjectHepatoprotective effectssr
dc.titleHepatoprotective effect of mixture of dipropyl polysulfides in concanavalin a-induced hepatitissr
dc.typearticlesr
dc.rights.licenseBYsr
dc.citation.volume13
dc.citation.issue3
dc.citation.spage1
dc.citation.epage15
dc.citation.rankM21~
dc.identifier.pmid33809904
dc.identifier.doi10.3390/nu13031022
dc.identifier.fulltexthttps://cer.ihtm.bg.ac.rs/bitstream/id/21044/nutrients-13-01022-v2.pdf
dc.identifier.scopus2-s2.0-85102752250
dc.identifier.wos000633943600001
dc.type.versionpublishedVersionsr


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