A chemically defined media consisting of carboxymethylcellulose (CMC) was developed to maximize the production of antibiotics, hexaene H-85 and azalomycine, by Streptomyces hygroscopicus CH-7. The production of antibiotics by filamentous organisms is often dependent on the morphology and size distribution of the pellet population within the culture. By adding the polymer to the fermentation medium, the growth was changed from a single large glob to small reproducible pellets, and wall growth was diminished to a minimum. Maximum concentrations of hexaene H-85 (146.7 mg/dm3) and azalomycine (188.6 mg/dm3) were reached at 3.0% and 1.0% (w/v) CMC, respectively.
TY - JOUR
AU - Ilić, Slavica B.
AU - Konstantinović, Sandra S.
AU - Veljković, Vlada B.
AU - Savić, D.S.
AU - Lazić, M. L.
AU - Gojgić-Cvijović, Gordana
PY - 2008
UR - http://cer.ihtm.bg.ac.rs/handle/123456789/479
AB - A chemically defined media consisting of carboxymethylcellulose (CMC) was developed to maximize the production of antibiotics, hexaene H-85 and azalomycine, by Streptomyces hygroscopicus CH-7. The production of antibiotics by filamentous organisms is often dependent on the morphology and size distribution of the pellet population within the culture. By adding the polymer to the fermentation medium, the growth was changed from a single large glob to small reproducible pellets, and wall growth was diminished to a minimum. Maximum concentrations of hexaene H-85 (146.7 mg/dm3) and azalomycine (188.6 mg/dm3) were reached at 3.0% and 1.0% (w/v) CMC, respectively.
T2 - Current Microbiology
T1 - Impact of carboxymethylcellulose on morphology and antibiotic production by Streptomyces hygroscopicus
VL - 57
IS - 1
SP - 8
EP - 11
DO - 10.1007/s00284-008-9143-7
ER -
@article{
author = "Ilić, Slavica B. and Konstantinović, Sandra S. and Veljković, Vlada B. and Savić, D.S. and Lazić, M. L. and Gojgić-Cvijović, Gordana",
year = "2008",
url = "http://cer.ihtm.bg.ac.rs/handle/123456789/479",
abstract = "A chemically defined media consisting of carboxymethylcellulose (CMC) was developed to maximize the production of antibiotics, hexaene H-85 and azalomycine, by Streptomyces hygroscopicus CH-7. The production of antibiotics by filamentous organisms is often dependent on the morphology and size distribution of the pellet population within the culture. By adding the polymer to the fermentation medium, the growth was changed from a single large glob to small reproducible pellets, and wall growth was diminished to a minimum. Maximum concentrations of hexaene H-85 (146.7 mg/dm3) and azalomycine (188.6 mg/dm3) were reached at 3.0% and 1.0% (w/v) CMC, respectively.",
journal = "Current Microbiology",
title = "Impact of carboxymethylcellulose on morphology and antibiotic production by Streptomyces hygroscopicus",
volume = "57",
number = "1",
pages = "8-11",
doi = "10.1007/s00284-008-9143-7"
}
Ilić SB, Konstantinović SS, Veljković VB, Savić D, Lazić ML, Gojgić-Cvijović G. Impact of carboxymethylcellulose on morphology and antibiotic production by Streptomyces hygroscopicus. Current Microbiology. 2008;57(1):8-11
Ilić, S. B., Konstantinović, S. S., Veljković, V. B., Savić, D.S., Lazić, M. L.,& Gojgić-Cvijović, G. (2008). Impact of carboxymethylcellulose on morphology and antibiotic production by Streptomyces hygroscopicus.
Current Microbiology, 57(1), 8-11.
https://doi.org/10.1007/s00284-008-9143-7
Ilić Slavica B., Konstantinović Sandra S., Veljković Vlada B., Savić D.S., Lazić M. L., Gojgić-Cvijović Gordana, "Impact of carboxymethylcellulose on morphology and antibiotic production by Streptomyces hygroscopicus" 57, no. 1 (2008):8-11,
https://doi.org/10.1007/s00284-008-9143-7 .
