Impact of carboxymethylcellulose on morphology and antibiotic production by Streptomyces hygroscopicus
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2008
Authors
Ilić, Slavica B.Konstantinović, Sandra S.

Veljković, Vlada B.

Savić, D.S.
Lazić, M. L.
Gojgić-Cvijović, Gordana

Article (Published version)

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Show full item recordAbstract
A chemically defined media consisting of carboxymethylcellulose (CMC) was developed to maximize the production of antibiotics, hexaene H-85 and azalomycine, by Streptomyces hygroscopicus CH-7. The production of antibiotics by filamentous organisms is often dependent on the morphology and size distribution of the pellet population within the culture. By adding the polymer to the fermentation medium, the growth was changed from a single large glob to small reproducible pellets, and wall growth was diminished to a minimum. Maximum concentrations of hexaene H-85 (146.7 mg/dm3) and azalomycine (188.6 mg/dm3) were reached at 3.0% and 1.0% (w/v) CMC, respectively.
Source:
Current Microbiology, 2008, 57, 1, 8-11
DOI: 10.1007/s00284-008-9143-7
ISSN: 0343-8651
PubMed: 18379844