Antiglioma action of xanthones from Gentiana kochiana: Mechanistic and structure-activity requirements
Само за регистроване кориснике
2008
Аутори
Isaković, AleksandraJanković, Teodora
Harhaji, Ljubica
Kostić Rajačić, Slađana
Nikolić, Zoran
Vajs, Vlatka
Trajković, Vladimir
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
The present study identifies xanthones gentiakochianin and gentiacaulein as the active principles responsible for the in vitro antiglioma action of ether and methanolic extracts of the plant Gentiana kochiana. Gentiakochianin and gentiacaulein induced cell cycle arrest in G2/M and G0/G1 phases, respectively, in both C6 rat glioma and U251 human glioma cell lines. The more efficient antiproliferative action of gentiakochianin was associated with its ability to induce microtubule stabilization in a cell-free assay. Both the xanthones reduced mitochondrial membrane potential and increased the production of reactive oxygen species in glioma cells, but only the effects of gentiakochianin were pronounced enough to cause caspase activation and subsequent apoptotic cell death. The assessment of structure-activity relationship in a series of structurally related xanthones from G. kochiana and Gentianella austriaca revealed dihydroxylation at positions 7, 8 of the xanthonic nucleus as the key st...ructural feature responsible for the ability of gentiakochianin to induce microtubule-associated G2/M cell block and apoptotic cell death in glioma cells.
Кључне речи:
Apoptosis / Cell cycle / Glioma / Oxidative stress / XanthoneИзвор:
Bioorganic and Medicinal Chemistry, 2008, 16, 10, 5683-5694Издавач:
- Oxford : Pergamon-Elsevier Science Ltd
Финансирање / пројекти:
- Цитотоксични, цитопротективни и имуномодулаторни ефекти наночестица (RS-MESTD-MPN2006-2010-145073)
- Секундарни метаболити самониклих, лековитих биљака: изоловање, карактеризација и билошка активност (RS-MESTD-MPN2006-2010-142053)
DOI: 10.1016/j.bmc.2008.03.069
ISSN: 0968-0896
PubMed: 18406151
WoS: 000256052400032
Scopus: 2-s2.0-43949101696
Институција/група
IHTMTY - JOUR AU - Isaković, Aleksandra AU - Janković, Teodora AU - Harhaji, Ljubica AU - Kostić Rajačić, Slađana AU - Nikolić, Zoran AU - Vajs, Vlatka AU - Trajković, Vladimir PY - 2008 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/478 AB - The present study identifies xanthones gentiakochianin and gentiacaulein as the active principles responsible for the in vitro antiglioma action of ether and methanolic extracts of the plant Gentiana kochiana. Gentiakochianin and gentiacaulein induced cell cycle arrest in G2/M and G0/G1 phases, respectively, in both C6 rat glioma and U251 human glioma cell lines. The more efficient antiproliferative action of gentiakochianin was associated with its ability to induce microtubule stabilization in a cell-free assay. Both the xanthones reduced mitochondrial membrane potential and increased the production of reactive oxygen species in glioma cells, but only the effects of gentiakochianin were pronounced enough to cause caspase activation and subsequent apoptotic cell death. The assessment of structure-activity relationship in a series of structurally related xanthones from G. kochiana and Gentianella austriaca revealed dihydroxylation at positions 7, 8 of the xanthonic nucleus as the key structural feature responsible for the ability of gentiakochianin to induce microtubule-associated G2/M cell block and apoptotic cell death in glioma cells. PB - Oxford : Pergamon-Elsevier Science Ltd T2 - Bioorganic and Medicinal Chemistry T1 - Antiglioma action of xanthones from Gentiana kochiana: Mechanistic and structure-activity requirements VL - 16 IS - 10 SP - 5683 EP - 5694 DO - 10.1016/j.bmc.2008.03.069 ER -
@article{ author = "Isaković, Aleksandra and Janković, Teodora and Harhaji, Ljubica and Kostić Rajačić, Slađana and Nikolić, Zoran and Vajs, Vlatka and Trajković, Vladimir", year = "2008", abstract = "The present study identifies xanthones gentiakochianin and gentiacaulein as the active principles responsible for the in vitro antiglioma action of ether and methanolic extracts of the plant Gentiana kochiana. Gentiakochianin and gentiacaulein induced cell cycle arrest in G2/M and G0/G1 phases, respectively, in both C6 rat glioma and U251 human glioma cell lines. The more efficient antiproliferative action of gentiakochianin was associated with its ability to induce microtubule stabilization in a cell-free assay. Both the xanthones reduced mitochondrial membrane potential and increased the production of reactive oxygen species in glioma cells, but only the effects of gentiakochianin were pronounced enough to cause caspase activation and subsequent apoptotic cell death. The assessment of structure-activity relationship in a series of structurally related xanthones from G. kochiana and Gentianella austriaca revealed dihydroxylation at positions 7, 8 of the xanthonic nucleus as the key structural feature responsible for the ability of gentiakochianin to induce microtubule-associated G2/M cell block and apoptotic cell death in glioma cells.", publisher = "Oxford : Pergamon-Elsevier Science Ltd", journal = "Bioorganic and Medicinal Chemistry", title = "Antiglioma action of xanthones from Gentiana kochiana: Mechanistic and structure-activity requirements", volume = "16", number = "10", pages = "5683-5694", doi = "10.1016/j.bmc.2008.03.069" }
Isaković, A., Janković, T., Harhaji, L., Kostić Rajačić, S., Nikolić, Z., Vajs, V.,& Trajković, V.. (2008). Antiglioma action of xanthones from Gentiana kochiana: Mechanistic and structure-activity requirements. in Bioorganic and Medicinal Chemistry Oxford : Pergamon-Elsevier Science Ltd., 16(10), 5683-5694. https://doi.org/10.1016/j.bmc.2008.03.069
Isaković A, Janković T, Harhaji L, Kostić Rajačić S, Nikolić Z, Vajs V, Trajković V. Antiglioma action of xanthones from Gentiana kochiana: Mechanistic and structure-activity requirements. in Bioorganic and Medicinal Chemistry. 2008;16(10):5683-5694. doi:10.1016/j.bmc.2008.03.069 .
Isaković, Aleksandra, Janković, Teodora, Harhaji, Ljubica, Kostić Rajačić, Slađana, Nikolić, Zoran, Vajs, Vlatka, Trajković, Vladimir, "Antiglioma action of xanthones from Gentiana kochiana: Mechanistic and structure-activity requirements" in Bioorganic and Medicinal Chemistry, 16, no. 10 (2008):5683-5694, https://doi.org/10.1016/j.bmc.2008.03.069 . .