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Synthesis, characterization, antimicrobial and cytotoxic activity and DNA-binding properties of d-metal complexes with hydrazones of Girard’s T and P reagents
dc.creator | Stevanović, Nevena | |
dc.creator | Mazzeo, Paolo Pio | |
dc.creator | Bacchi, Alessia | |
dc.creator | Matić, Ivana Z. | |
dc.creator | Đorđić Crnogorac, Marija | |
dc.creator | Stanojković, Tatjana | |
dc.creator | Vujčić, Miroslava | |
dc.creator | Novaković, Irena | |
dc.creator | Radanović, Dušanka | |
dc.creator | Šumar‑Ristović, Maja | |
dc.creator | Sladić, Dušan | |
dc.creator | Čobeljić, Božidar | |
dc.creator | Anđelković, Katarina | |
dc.date.accessioned | 2021-10-01T09:23:19Z | |
dc.date.available | 2021-10-01T09:23:19Z | |
dc.date.issued | 2021 | |
dc.identifier.issn | 0949-8257 | |
dc.identifier.uri | https://cer.ihtm.bg.ac.rs/handle/123456789/4769 | |
dc.description.abstract | In this work synthesis, characterization and crystal structures of 1, Zn(II) complex ([ZnL1(NCS)2]), with (E)-1-(2-oxo-2-(2-(quinolin-2-ylmethylene)hydrazinyl)ethyl)pyridin-1-ium chloride (HL1Cl) and 2, Bi(III) complex ([BiHL2Cl4] × 1/2CH3OH), with (E)-N,N,N-trimethyl-2-oxo-2-(2-(1-(thiazol-2-yl)ethylidene)hydrazinyl)ethan-1-aminium chloride (HL2Cl), have been reported. Zn(II) complex possesses a distorted trigonal bipyramidal geometry while surroundings around Bi(III) ion are extended pentagonal bipyramidal. Antimicrobial activity, brine shrimp assay and DPPH radical scavenging activity of both complexes, including previously synthesized complexes with HL2Cl ligand (Zn(II) and Ni(II)) and complexes with (E)-N,N,N-trimethyl-2-oxo-2-(2-(1-(pyridin-2-yl)ethylidene)hydrazinyl)ethan-1-aminium chloride (HL3Cl) (Zn(II), Cu(II), Cd(II), Co(II), Fe(III), Ni(II)), were evaluated. For the most active complexes, cytotoxic activity against five malignant cancer cell lines (HeLa, A375, MCF7, PC-3 and A549) and normal cell line HaCaT, as well as generation of reactive oxygen species (ROS), was tested. Graphic abstract: [Figure not available: see fulltext.] | sr |
dc.language.iso | en | sr |
dc.publisher | Springer Science and Business Media Deutschland GmbH | sr |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200026/RS// | sr |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200168/RS// | sr |
dc.relation | The Italian Ministry for Education, University and Research (MIUR, 2018-2022). | sr |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/20004/RS// | sr |
dc.rights | restrictedAccess | sr |
dc.source | Journal of Biological Inorganic Chemistry | sr |
dc.subject | Antimicrobial activity | sr |
dc.subject | Cytotoxic activity | sr |
dc.subject | DNA-binding experiments | sr |
dc.subject | Hydrazone complexes | sr |
dc.subject | ROS | sr |
dc.subject | X-ray | sr |
dc.title | Synthesis, characterization, antimicrobial and cytotoxic activity and DNA-binding properties of d-metal complexes with hydrazones of Girard’s T and P reagents | sr |
dc.type | article | sr |
dc.rights.license | ARR | sr |
dcterms.abstract | Aнђелковић, Катарина; Радановић, Душанка; Шумар‑Ристовић, Маја; Сладић, Душан; Вујчић, Мирослава; Станојковић, Татјана; Ђорђић Црногорац, Марија; Матић, Ивана З.; Стевановић, Невена; Маззео, Паоло Пио; Баццхи, Aлессиа; Чобељић, Божидар; Новаковић, Ирена; | |
dc.citation.rank | M21~ | |
dc.identifier.pmid | 34487214 | |
dc.identifier.doi | 10.1007/s00775-021-01893-5 | |
dc.identifier.scopus | 2-s2.0-85114304815 | |
dc.identifier.wos | 000695511900001 | |
dc.type.version | publishedVersion | sr |