Carbohydrazones and their thio analogs represent compounds obtained by condensation of carbohydrazide and thiocarbohydrazide with carbonyl compounds. Due to their structure, relatively simple synthesis, and high reactivity, mentioned derivatives have a wide range of applications in all fields. In this study, ionization constants of four newly synthesized mono(thio)carbohydrazones were determined by applying the potentiometric method. Also, the influence of specific
and nonspecific intermolecular interactions on maxima shifting in UV-Vis absorption spectra was investigated and quantified using the linear solvation energy relationships method and Catalan’s model. Finally, by applying the DPPH assay, the antioxidant potential of the newly synthesized compounds was determined, and thiocarbohydrazone derivatives proved to be significantly more active when compared to carbohydrazones.
TY - CONF
AU - Mrđan, Gorana
AU - Vaštag, Đenđi
AU - Apostolov, Suzana
AU - Rašeta, Milena
AU - Verbić, Tatjana
AU - Marković, Olivera
AU - Matijević, Borko
PY - 2021
UR - https://cer.ihtm.bg.ac.rs/handle/123456789/4760
AB - Carbohydrazones and their thio analogs represent compounds obtained by condensation of carbohydrazide and thiocarbohydrazide with carbonyl compounds. Due to their structure, relatively simple synthesis, and high reactivity, mentioned derivatives have a wide range of applications in all fields. In this study, ionization constants of four newly synthesized mono(thio)carbohydrazones were determined by applying the potentiometric method. Also, the influence of specific
and nonspecific intermolecular interactions on maxima shifting in UV-Vis absorption spectra was investigated and quantified using the linear solvation energy relationships method and Catalan’s model. Finally, by applying the DPPH assay, the antioxidant potential of the newly synthesized compounds was determined, and thiocarbohydrazone derivatives proved to be significantly more active when compared to carbohydrazones.
C3 - Programme and the book of abstracts, 14th International Scientific Conference Contemporary Materials 2021
T1 - Investigation of physicochemical properties and potential biological activity of 2-pyridine-(thio)carbohydrazone derivatives
SP - 40
EP - 40
UR - https://hdl.handle.net/21.15107/rcub_cer_4760
ER -
@conference{
author = "Mrđan, Gorana and Vaštag, Đenđi and Apostolov, Suzana and Rašeta, Milena and Verbić, Tatjana and Marković, Olivera and Matijević, Borko",
year = "2021",
abstract = "Carbohydrazones and their thio analogs represent compounds obtained by condensation of carbohydrazide and thiocarbohydrazide with carbonyl compounds. Due to their structure, relatively simple synthesis, and high reactivity, mentioned derivatives have a wide range of applications in all fields. In this study, ionization constants of four newly synthesized mono(thio)carbohydrazones were determined by applying the potentiometric method. Also, the influence of specific
and nonspecific intermolecular interactions on maxima shifting in UV-Vis absorption spectra was investigated and quantified using the linear solvation energy relationships method and Catalan’s model. Finally, by applying the DPPH assay, the antioxidant potential of the newly synthesized compounds was determined, and thiocarbohydrazone derivatives proved to be significantly more active when compared to carbohydrazones.",
journal = "Programme and the book of abstracts, 14th International Scientific Conference Contemporary Materials 2021",
title = "Investigation of physicochemical properties and potential biological activity of 2-pyridine-(thio)carbohydrazone derivatives",
pages = "40-40",
url = "https://hdl.handle.net/21.15107/rcub_cer_4760"
}
Mrđan, G., Vaštag, Đ., Apostolov, S., Rašeta, M., Verbić, T., Marković, O.,& Matijević, B.. (2021). Investigation of physicochemical properties and potential biological activity of 2-pyridine-(thio)carbohydrazone derivatives. in Programme and the book of abstracts, 14th International Scientific Conference Contemporary Materials 2021, 40-40.
https://hdl.handle.net/21.15107/rcub_cer_4760
Mrđan G, Vaštag Đ, Apostolov S, Rašeta M, Verbić T, Marković O, Matijević B. Investigation of physicochemical properties and potential biological activity of 2-pyridine-(thio)carbohydrazone derivatives. in Programme and the book of abstracts, 14th International Scientific Conference Contemporary Materials 2021. 2021;:40-40.
https://hdl.handle.net/21.15107/rcub_cer_4760 .
Mrđan, Gorana, Vaštag, Đenđi, Apostolov, Suzana, Rašeta, Milena, Verbić, Tatjana, Marković, Olivera, Matijević, Borko, "Investigation of physicochemical properties and potential biological activity of 2-pyridine-(thio)carbohydrazone derivatives" in Programme and the book of abstracts, 14th International Scientific Conference Contemporary Materials 2021 (2021):40-40,
https://hdl.handle.net/21.15107/rcub_cer_4760 .
