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dc.creatorBaošić, R.
dc.creatorRadojević, A.
dc.creatorRadulović, Milanka
dc.creatorMiletić, Srđan
dc.creatorNatić, Maja
dc.creatorTešić, Živoslav
dc.date.accessioned2019-01-30T17:19:01Z
dc.date.available2019-01-30T17:19:01Z
dc.date.issued2008
dc.identifier.issn0269-3879
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/474
dc.description.abstractThe lipophilicity of a series of Schiff base ligands and their complexes with nickel(II) and copper(II) has been determined by reversed-phase thin-layer chromatography using binary dioxane-water mobile phase. Chelate ligands were prepared by condensation of diamine and the corresponding β-diketone. Copper(II) and nickel(II) complexes with chelate ligands containing ethane-1,2-diamine or propane-1,2-diamine as the amine part and pentane-2,4-dione and/or 1-phenylbutane-1,3-dione, pentane-2,4-dione and/or 1,1,1-trifluoropentane-2,4-dione, or 1,1,1-trifluoropentane-2,4-dione and/or 1-phenylbutane-1,3-dione as the β-diketone part were synthesized. Some of investigated compounds were screened for their in vitro antifungal activity against Sacharomyces cerevisiae and antibacterial activity against Escherichia coli. Chromatographically obtained lipophilicity parameters were correlated both with calculated n-octanol-water partition coefficient C log P and antimicrobial activities. Satisfactory correlations were obtained. Chromatographic data proved to be reliable parameters for describing the lipophilic properties of the investigated compounds. Additionally, the principal components analysis was performed on the data chromatographically obtained. This statistical method was useful for distinguishing compounds and objective comparison of their lipophilicity parameters. Copyrighten
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/142062/RS//
dc.rightsrestrictedAccess
dc.sourceBiomedical Chromatography
dc.subjectAntimicrobial activityen
dc.subjectLipophilicityen
dc.subjectReversed-phase thin-layer chromatographyen
dc.subjectStructure-activity relationshipen
dc.subjectStructure-retention relationshipen
dc.titleRelationships between structure, retention and biological activity of some Schiff base ligands and their complexesen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractМилетић, Срђан; Радуловић, М.; Радојевић, A.; Баошић, Р.; Натић, М.; Тешић, З.;
dc.citation.volume22
dc.citation.issue4
dc.citation.spage379
dc.citation.epage386
dc.citation.other22(4): 379-386
dc.citation.rankM22
dc.identifier.pmid18059055
dc.identifier.doi10.1002/bmc.943
dc.identifier.rcubConv_4153
dc.identifier.scopus2-s2.0-42549171928
dc.identifier.wos000255133300007
dc.type.versionpublishedVersion


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