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dc.creatorOpsenica, Igor
dc.creatorOpsenica, Dejan
dc.creatorSmith, K. S.
dc.creatorMilhous, Wilbur K.
dc.creatorŠolaja, Bogdan
dc.date.accessioned2019-01-30T17:18:55Z
dc.date.available2019-01-30T17:18:55Z
dc.date.issued2008
dc.identifier.issn0022-2623
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/471
dc.description.abstractOf 17 prepared 1,2,4,5-tetraoxacyclohexanes stable to reductive and acidic conditions, 3 of them were more active than artemisinin against CQ and MFQ resistant strain TM91C235 and all compounds were more active in vitro against W2 than against D6 strain. In vivo, amines 10 and 11a cured all mice at higher doses with MCD ≤ 37.5 (mg/kg)/day. Triol 13 was exceptionally active against melanoma (LOX IMVI) and ovarian cancer (IGROV1), both with LC 50 = 60 nM.en
dc.publisherAmer Chemical Soc, Washington
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/142022/RS//
dc.rightsrestrictedAccess
dc.sourceJournal of Medicinal Chemistry
dc.titleChemical stability of the peroxide bond enables diversified synthesis of potent tetraoxane antimalarialsen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractОпсеница, И.; Шолаја, Б.A.; Опсеница, Дејан; Милхоус, W.К.; Смитх, К.С.;
dc.citation.volume51
dc.citation.issue7
dc.citation.spage2261
dc.citation.epage2266
dc.citation.other51(7): 2261-2266
dc.citation.rankaM21
dc.identifier.pmid18330976
dc.identifier.doi10.1021/jm701417a
dc.identifier.rcubConv_4143
dc.identifier.scopus2-s2.0-41849117634
dc.identifier.wos000254709100031
dc.type.versionpublishedVersion


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