Приказ основних података о документу

dc.creatorBukvicki, Danka
dc.creatorNovaković, Miroslav
dc.creatorIlić - Tomić, Tatjana
dc.creatorNikodinović-Runić, Jasmina
dc.creatorTodorović, Nina
dc.creatorVeljić, Milan
dc.creatorAsakawa, Yoshinori
dc.date.accessioned2021-05-18T09:03:25Z
dc.date.available2021-05-18T09:03:25Z
dc.date.issued2021
dc.identifier.issn1307-6167
dc.identifier.urihttps://cer.ihtm.bg.ac.rs/handle/123456789/4630
dc.description.abstractBiotransformation of bis-bibenzyl perrottetin F (1), isolated from the liverwort Lunularia cruciata by Aspergillus niger, has been investigated. New metabolites (2-4) have been isolated using reversed phase semipreparative HPLC and their structures were established to be 8-hydroxyperrottetin F, C-7-C-8 cleaved product, and perrottetin F 6’-sulfate using 1D and 2D NMR, HR-ESI-MS, IR and UV spectroscopy. The antimicrobial and cytotoxic properties of these compounds were also evaluated. Given the suggested cytotoxic properties of the parent compound, antiproliferative activity against healthy human lung fibroblasts (MRC5) and human lung carcinoma (A549) of three metabolites were evaluated revealing their lower cytotoxic properties in comparison to the starting compound-perrottetin F. The antimicrobial properties of these compounds were also evaluated, with the inhibitory activity against the Pseudomonas aeruginosa PAO1 and Staphylococcus aureus determined between 100 µM and 450 µM. The metabolites showed remarkable ability to inhibit synthesis of bacterial quorum-sensing signal molecules such as short chain acyl homoserine lactones (AHLs). Therefore, biotransformation method represents fast and effective tool for obtaining new bioactive structures.sr
dc.language.isoensr
dc.publisherTürkiye : ACG Publicationssr
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200178/RS//sr
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200042/RS//sr
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200026/RS//sr
dc.relationThe Matsumae International Foundationsr
dc.rightsopenAccesssr
dc.sourceRecords of Natural Productssr
dc.subject1D and 2D NMRsr
dc.subjectAspergillus nigersr
dc.subjectBiotransformationsr
dc.subjectCytotoxic activitysr
dc.subjectLiverwortssr
dc.subjectPerrottetin Fsr
dc.titleBiotransformation of Perrottetin F by Aspergillus niger: New Bioactive Secondary Metabolitessr
dc.typearticlesr
dc.rights.licenseARRsr
dcterms.abstractНикодиновић-Рунић, Јасмина; Aсакаwа, Yосхинори; Илић - Томић, Татјана; Новаковић, Мирослав; Буквицки, Данка; Вељић, Милан; Тодоровић, Нина;
dc.citation.volume15
dc.citation.issue4
dc.citation.spage281
dc.citation.epage292
dc.citation.rankM22~
dc.identifier.doi10.25135/rnp.215.20.09.1812
dc.identifier.fulltexthttps://cer.ihtm.bg.ac.rs/bitstream/id/20413/20210417111946A6-215-RNP-2009-1812.pdf
dc.identifier.scopus2-s2.0-85105008970
dc.identifier.wos000641301200006
dc.type.versionpublishedVersionsr


Документи

Thumbnail

Овај документ се појављује у следећим колекцијама

Приказ основних података о документу