Assessment of hot-melt coating methods for multiparticulate substrates: Mortar-coating vs. pan-coating
Procena metoda za oblaganje višečestičnih supstrata topljenjem: oblaganje u pateni vs. oblaganje u bubnju
Authors
Ignjatović, JelisavetaĐuriš, Jelena

Đuriš, Mihal

Bočarski, Teodora
Vasiljević, Vanja
Aleksić, Ivana

Cvijić, Sandra

Article (Published version)
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Hot-melt coating (HMC) is an alternative, solvent-free coating method generally used to modify substrate release rate and/or mask its unpleasant taste. The aim of this study was to assess two HMC methods (pan-coating and mortar-coating) by assaying functional properties of the coated material. The selected substrates included highly soluble sodium chloride (model substance) and caffeine (bitter drug), and the coating agent was glycerol distearate without/with the addition of liquid paraffin. Experiments with sodium chloride revealed that pan-coating yielded particles of more regular shape, while mortar-coating yielded samples of more uniform coating layer. The flowability of the coated material depended on the particle size. Sustained sodium chloride release was achieved for all mortar-coated and some pan-coated samples. The analysis of the results indicated mortar-coating as a preferable HMC method for caffeine coating. The resulting caffeine yield in the coated samples was high (99%)..., the material showed satisfactory mechanical properties and drug release from the coated particles was sustained. Overall, the obtained results suggest that both pan-and mortar-coating can be used to sustain the release of drugs with unpleasant taste, but mortar-coating can be considered as a more simple and practical method that can be potentially used in compounding pharmacies.
Oblaganje topljenjem je alternativna metoda oblaganja, bez upotrebe rastvarača i uglavnom
se koristi za modifikaciju brzine rastvaranja i/ili maskiranje neprijatnog ukusa supstrata. Cilj ovog
rada je da se procene dve metode za oblaganje topljenjem (oblaganje u bubnju i oblaganje u
pateni), ispitivanjem funkcionalnih karakteristika obloženog materijala. Izabrana su dva visoko
rastvorljiva supstrata: natrijum-hlorid (model supstanca) i kofein (lekovita supstanca gorkog
ukusa), a za oblaganje je korišćen glicerildistearat bez/sa dodatkom tečnog parafina.
Eksperimenti sa natrijum-hloridom su pokazali da su oblaganjem u bubnju dobijene čestice
pravilnijeg oblika, dok su oblaganjem u pateni dobijeni uzorci sa ujednačenijom oblogom.
Protočnost obloženog materijala je zavisila od veličine čestica. Usporeno rastvaranje natrijumhlorida
postignuto je kod svih uzoraka obloženih u pateni i kod nekih uzoraka obloženih u bubnju.
Analiza rezultata je izdvojila oblaganje u pateni kao pogodni...ju metodu za oblaganje kofeina.
Dobijeni prinos obloženih čestica kofeina je bio visok (99%), obloženi materijal je imao
zadovoljavajuće mehaničke osobine i postignuta je usporena brzina rastvaranja kofeina. Sumarno,
dobijeni rezultati su pokazali da se i oblaganje u bubnju i u pateni mogu koristiti za usporavanje
rastvaranja lekovitih supstanci neprijatnog ukusa, no oblaganje u pateni predstavlja jednostavniju
i praktičniju metodu koja se potencijalno može koristiti i u izradi magistralnih lekova.
Keywords:
Functional propertiesHot-melt coatingMortar-coatingMultiparticulatesPan-coating / Functional properties / Hot-melt coating / Mortar-coating / Multiparticulates / Pan-coating / oblaganje topljenjem / oblaganje u bubnju / oblaganje u pateni / višečestični sistemi / funkcionalne karakteristikeSource:
Arhiv za Farmaciju, 2021, 71, 1, 35-54Publisher:
- Serbia : Pharmaceutical Association of Serbia
Funding / projects:
Collections
Institution/Community
IHTMTY - JOUR AU - Ignjatović, Jelisaveta AU - Đuriš, Jelena AU - Đuriš, Mihal AU - Bočarski, Teodora AU - Vasiljević, Vanja AU - Aleksić, Ivana AU - Cvijić, Sandra PY - 2021 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/4527 AB - Hot-melt coating (HMC) is an alternative, solvent-free coating method generally used to modify substrate release rate and/or mask its unpleasant taste. The aim of this study was to assess two HMC methods (pan-coating and mortar-coating) by assaying functional properties of the coated material. The selected substrates included highly soluble sodium chloride (model substance) and caffeine (bitter drug), and the coating agent was glycerol distearate without/with the addition of liquid paraffin. Experiments with sodium chloride revealed that pan-coating yielded particles of more regular shape, while mortar-coating yielded samples of more uniform coating layer. The flowability of the coated material depended on the particle size. Sustained sodium chloride release was achieved for all mortar-coated and some pan-coated samples. The analysis of the results indicated mortar-coating as a preferable HMC method for caffeine coating. The resulting caffeine yield in the coated samples was high (99%), the material showed satisfactory mechanical properties and drug release from the coated particles was sustained. Overall, the obtained results suggest that both pan-and mortar-coating can be used to sustain the release of drugs with unpleasant taste, but mortar-coating can be considered as a more simple and practical method that can be potentially used in compounding pharmacies. AB - Oblaganje topljenjem je alternativna metoda oblaganja, bez upotrebe rastvarača i uglavnom se koristi za modifikaciju brzine rastvaranja i/ili maskiranje neprijatnog ukusa supstrata. Cilj ovog rada je da se procene dve metode za oblaganje topljenjem (oblaganje u bubnju i oblaganje u pateni), ispitivanjem funkcionalnih karakteristika obloženog materijala. Izabrana su dva visoko rastvorljiva supstrata: natrijum-hlorid (model supstanca) i kofein (lekovita supstanca gorkog ukusa), a za oblaganje je korišćen glicerildistearat bez/sa dodatkom tečnog parafina. Eksperimenti sa natrijum-hloridom su pokazali da su oblaganjem u bubnju dobijene čestice pravilnijeg oblika, dok su oblaganjem u pateni dobijeni uzorci sa ujednačenijom oblogom. Protočnost obloženog materijala je zavisila od veličine čestica. Usporeno rastvaranje natrijumhlorida postignuto je kod svih uzoraka obloženih u pateni i kod nekih uzoraka obloženih u bubnju. Analiza rezultata je izdvojila oblaganje u pateni kao pogodniju metodu za oblaganje kofeina. Dobijeni prinos obloženih čestica kofeina je bio visok (99%), obloženi materijal je imao zadovoljavajuće mehaničke osobine i postignuta je usporena brzina rastvaranja kofeina. Sumarno, dobijeni rezultati su pokazali da se i oblaganje u bubnju i u pateni mogu koristiti za usporavanje rastvaranja lekovitih supstanci neprijatnog ukusa, no oblaganje u pateni predstavlja jednostavniju i praktičniju metodu koja se potencijalno može koristiti i u izradi magistralnih lekova. PB - Serbia : Pharmaceutical Association of Serbia T2 - Arhiv za Farmaciju T1 - Assessment of hot-melt coating methods for multiparticulate substrates: Mortar-coating vs. pan-coating T1 - Procena metoda za oblaganje višečestičnih supstrata topljenjem: oblaganje u pateni vs. oblaganje u bubnju VL - 71 IS - 1 SP - 35 EP - 54 DO - 10.5937/arhfarm71-30266 ER -
@article{ author = "Ignjatović, Jelisaveta and Đuriš, Jelena and Đuriš, Mihal and Bočarski, Teodora and Vasiljević, Vanja and Aleksić, Ivana and Cvijić, Sandra", year = "2021", abstract = "Hot-melt coating (HMC) is an alternative, solvent-free coating method generally used to modify substrate release rate and/or mask its unpleasant taste. The aim of this study was to assess two HMC methods (pan-coating and mortar-coating) by assaying functional properties of the coated material. The selected substrates included highly soluble sodium chloride (model substance) and caffeine (bitter drug), and the coating agent was glycerol distearate without/with the addition of liquid paraffin. Experiments with sodium chloride revealed that pan-coating yielded particles of more regular shape, while mortar-coating yielded samples of more uniform coating layer. The flowability of the coated material depended on the particle size. Sustained sodium chloride release was achieved for all mortar-coated and some pan-coated samples. The analysis of the results indicated mortar-coating as a preferable HMC method for caffeine coating. The resulting caffeine yield in the coated samples was high (99%), the material showed satisfactory mechanical properties and drug release from the coated particles was sustained. Overall, the obtained results suggest that both pan-and mortar-coating can be used to sustain the release of drugs with unpleasant taste, but mortar-coating can be considered as a more simple and practical method that can be potentially used in compounding pharmacies., Oblaganje topljenjem je alternativna metoda oblaganja, bez upotrebe rastvarača i uglavnom se koristi za modifikaciju brzine rastvaranja i/ili maskiranje neprijatnog ukusa supstrata. Cilj ovog rada je da se procene dve metode za oblaganje topljenjem (oblaganje u bubnju i oblaganje u pateni), ispitivanjem funkcionalnih karakteristika obloženog materijala. Izabrana su dva visoko rastvorljiva supstrata: natrijum-hlorid (model supstanca) i kofein (lekovita supstanca gorkog ukusa), a za oblaganje je korišćen glicerildistearat bez/sa dodatkom tečnog parafina. Eksperimenti sa natrijum-hloridom su pokazali da su oblaganjem u bubnju dobijene čestice pravilnijeg oblika, dok su oblaganjem u pateni dobijeni uzorci sa ujednačenijom oblogom. Protočnost obloženog materijala je zavisila od veličine čestica. Usporeno rastvaranje natrijumhlorida postignuto je kod svih uzoraka obloženih u pateni i kod nekih uzoraka obloženih u bubnju. Analiza rezultata je izdvojila oblaganje u pateni kao pogodniju metodu za oblaganje kofeina. Dobijeni prinos obloženih čestica kofeina je bio visok (99%), obloženi materijal je imao zadovoljavajuće mehaničke osobine i postignuta je usporena brzina rastvaranja kofeina. Sumarno, dobijeni rezultati su pokazali da se i oblaganje u bubnju i u pateni mogu koristiti za usporavanje rastvaranja lekovitih supstanci neprijatnog ukusa, no oblaganje u pateni predstavlja jednostavniju i praktičniju metodu koja se potencijalno može koristiti i u izradi magistralnih lekova.", publisher = "Serbia : Pharmaceutical Association of Serbia", journal = "Arhiv za Farmaciju", title = "Assessment of hot-melt coating methods for multiparticulate substrates: Mortar-coating vs. pan-coating, Procena metoda za oblaganje višečestičnih supstrata topljenjem: oblaganje u pateni vs. oblaganje u bubnju", volume = "71", number = "1", pages = "35-54", doi = "10.5937/arhfarm71-30266" }
Ignjatović, J., Đuriš, J., Đuriš, M., Bočarski, T., Vasiljević, V., Aleksić, I.,& Cvijić, S.. (2021). Assessment of hot-melt coating methods for multiparticulate substrates: Mortar-coating vs. pan-coating. in Arhiv za Farmaciju Serbia : Pharmaceutical Association of Serbia., 71(1), 35-54. https://doi.org/10.5937/arhfarm71-30266
Ignjatović J, Đuriš J, Đuriš M, Bočarski T, Vasiljević V, Aleksić I, Cvijić S. Assessment of hot-melt coating methods for multiparticulate substrates: Mortar-coating vs. pan-coating. in Arhiv za Farmaciju. 2021;71(1):35-54. doi:10.5937/arhfarm71-30266 .
Ignjatović, Jelisaveta, Đuriš, Jelena, Đuriš, Mihal, Bočarski, Teodora, Vasiljević, Vanja, Aleksić, Ivana, Cvijić, Sandra, "Assessment of hot-melt coating methods for multiparticulate substrates: Mortar-coating vs. pan-coating" in Arhiv za Farmaciju, 71, no. 1 (2021):35-54, https://doi.org/10.5937/arhfarm71-30266 . .