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dc.creatorŚolaja, B.A.
dc.creatorOpsenica, Dejan
dc.creatorSmith, K. S.
dc.creatorMilhous, Wilbur K.
dc.creatorTerzić, Nataša
dc.creatorOpsenica, Igor
dc.creatorBurnett, J.C.
dc.creatorNuss, J.
dc.creatorGussio, R.
dc.creatorBavari, S.
dc.date.accessioned2019-01-30T17:18:31Z
dc.date.available2019-01-30T17:18:31Z
dc.date.issued2008
dc.identifier.issn0022-2623
dc.identifier.urihttps://cer.ihtm.bg.ac.rs/handle/123456789/451
dc.description.abstractWe report on the initial result of the coupling of 4-amino-7- chloroquinoline with steroidal and adamantane constituents to provide small molecules with excellent in vitro antimalarial activities (IC90 (W2) down to 6.74 nM). The same entities also inhibit the botulinum neurotoxin serotype A light chain metalloprotease at low micromolar levels (7-31 μM). Interestingly, structural features imparting increased antimalarial activity also provide increased metalloprotease inhibition, thus allowing for simultaneous compound optimizations against distinct targets.en
dc.publisherAmerican Chemical Society (ACS)
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/142022/RS//
dc.rightsrestrictedAccess
dc.sourceJournal of Medicinal Chemistry
dc.titleNovel 4-aminoquinolines active against chloroquine-resistant and sensitive P. falciparum strains that also inhibit botulinum serotype Aen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractМилхоус, W.К.; Смитх, К.С.; Śолаја, Б.A.; Нусс, Ј.; Опсеница, И.; Опсеница, Дејан; Бавари, С.; Гуссио, Р.; Бурнетт, Ј.Ц.; Терзић, Н.;
dc.citation.volume51
dc.citation.issue15
dc.citation.spage4388
dc.citation.epage4391
dc.citation.other51(15): 4388-4391
dc.citation.rankaM21
dc.identifier.pmid18637666
dc.identifier.doi10.1021/jm800737y
dc.identifier.scopus2-s2.0-49449118829
dc.identifier.wos000258289800007
dc.type.versionpublishedVersion


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