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dc.creatorAndrić, Deana
dc.creatorRoglić, Goran
dc.creatorŠukalović, Vladimir
dc.creatorŠoškić, Vukić
dc.creatorKostić Rajačić, Slađana
dc.date.accessioned2019-01-30T17:18:30Z
dc.date.available2019-01-30T17:18:30Z
dc.date.issued2008
dc.identifier.issn0223-5234
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/449
dc.description.abstractIn this publication we are describing synthesis, binding properties, and receptor docking of 4-halo-6-[2-(4-arylpiperazin-1-yl)ethyl]-1H-benzimidazoles, a new compounds with potential antipsychotics properties. Affinity towards the dopamine D1-like and D2-like, and serotonin 5-HT1A receptors was evaluated using the radioligand binding assays. All compounds tested had affinity for the D2-like and 5-HT1A receptors, but were inactive towards the D1-like receptor. Halogenated 6-[2-(4-arylpiperazin-1-yl)ethyl]-1H-benzimidazoles showed higher affinity compared to their nonhalogenated congeners. In silico docking analysis of selected ligands was performed in order to explain the results of binding assays. Our analysis suggests that stabilizing interactions between the halogen atom at the benzimidazole ring and the Ser-122 of the D2-like and Trp-358 of the 5-HT1A receptor. Energy contributions for these interactions were calculated using the ab initio method.en
dc.publisherElsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/142009/RS//
dc.rightsrestrictedAccess
dc.sourceEuropean Journal of Medicinal Chemistry
dc.subjectDopamine receptoren
dc.subjectRational drug designen
dc.subjectSerotonin receptoren
dc.titleSynthesis, binding properties and receptor docking of 4-halo-6-[2-(4-arylpiperazin-1-yl)ethyl]-1H-benzimidazoles, mixed ligands of D2 and 5-HT1A receptorsen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractШукаловић, Владимир; Aндрић, Д.; Костић Рајачић, Слађана; Шошкић, В.; Роглић, Г.;
dc.citation.volume43
dc.citation.issue8
dc.citation.spage1696
dc.citation.epage1705
dc.citation.other43(8): 1696-1705
dc.citation.rankM22
dc.identifier.pmid18006194
dc.identifier.doi10.1016/j.ejmech.2007.09.027
dc.identifier.rcubConv_4164
dc.identifier.scopus2-s2.0-48049117780
dc.identifier.wos000259161600014
dc.type.versionpublishedVersion


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