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dc.creatorOpsenica, Igor
dc.creatorOpsenica, Dejan
dc.creatorLanteri, C.A.
dc.creatorAnova, L.
dc.creatorMilhous, Wilbur K.
dc.creatorSmith, K. S.
dc.creatorŠolaja, Bogdan
dc.date.accessioned2019-01-30T17:18:29Z
dc.date.available2019-01-30T17:18:29Z
dc.date.issued2008
dc.identifier.issn0022-2623
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/448
dc.description.abstractThe synthesis of the chimeric molecules consisting of two pharmacophores, tetraoxane and 7-chloro-4-aminoquinoline, is reported. The tetraoxanes 2, 4, and 8 show relatively potent in vitro antimalarial activities, with IC90 values for the Plasmodium falciparum strain W2 of 2.26, 12.44, and 10.74 nM, respectively. In addition, two compounds, 2 and 4, cured mice in a modified Thompson test for antimalarial blood stage activity, with a minimum curative dose of 80 mg/kg, a minimum active dose of 20 mg/kg/day, and a maximum tolerated dose of >960 mg/kg.en
dc.publisherAmerican Chemical Society (ACS)
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/142022/RS//
dc.rightsrestrictedAccess
dc.sourceJournal of Medicinal Chemistry
dc.titleNew chimeric antimalarials with 4-aminoquinoline moiety linked to a tetraoxane skeletonen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractОпсеница, Дејан; Опсеница, И.; Милхоус, W.К.; Лантери, Ц.A.; Шолаја, Б.A.; Смитх, К.С.; Aнова, Л.;
dc.citation.volume51
dc.citation.issue19
dc.citation.spage6216
dc.citation.epage6219
dc.citation.other51(19): 6216-6219
dc.citation.rankaM21
dc.identifier.pmid18774792
dc.identifier.doi10.1021/jm8006905
dc.identifier.rcubConv_4170
dc.identifier.scopus2-s2.0-53549086186
dc.identifier.wos000259760500040
dc.type.versionpublishedVersion


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