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dc.creatorSenerovic, Lidija
dc.creatorMoric, Ivana
dc.creatorMilivojevic, Dusan
dc.creatorOpsenica, Dejan
dc.date.accessioned2021-04-16T12:24:07Z
dc.date.available2021-04-16T12:24:07Z
dc.date.issued2020
dc.identifier.isbn978-0-12-819541-3
dc.identifier.urihttps://cer.ihtm.bg.ac.rs/handle/123456789/4459
dc.description.abstractThe rapid emergence of antibiotic-resistant pathogens presents a global healthcare challenge. Bacteria control their virulence, motility, and biofilm formation, all of them being required for establishing pathogenicity, through a cell density-dependent communication system known as quorum sensing (QS). QS comprises production of extracellular signaling molecules, their detection, and population-wide response involving regulation of the virulence genes expression. Inhibition of QS affects virulence and reduces harmful effects to the host and as such presents a promising strategy to fight antibiotic-resistant infections. Multiresistant Pseudomonas aeruginosa belogns to the group of most critical pathogens for which the introduction of new therapeutics is imperative. In the search for novel therapeutics nature continues to be inexhaustible source of bioactive scaffolds, which provide the bases for structure-based rational drug design enabling further exploitation of diverse natural structures. This review describes bacterial QS systems, highlights strategies for their manipulation, overviews nature-inspired antivirulence molecules primarily against P. aeruginosa, and discusses their perspectives.
dc.publisherElsevieren
dc.rightsrestrictedAccess
dc.sourceBiodiversity and Biomedicine
dc.subjectAntibiotic resistance
dc.subjectantivirulence
dc.subjectautoinducer
dc.subjectbiofilm
dc.subjectPseudomonas aeruginosa
dc.subjectquorum sensing
dc.subjectsynthetic inhibitor
dc.titleNature-inspired synthetic analogues of quorum sensing signaling molecules as novel therapeutics against Pseudomonas aeruginosa infectionsen
dc.typebookParten
dc.rights.licenseARR
dcterms.abstractМиливојевиц, Дусан; Опсеница, Дејан; Сенеровиц, Лидија; Мориц, Ивана;
dc.citation.spage497
dc.citation.epage523
dc.citation.rankM13
dc.identifier.doi10.1016/B978-0-12-819541-3.00025-6
dc.type.versionpublishedVersion


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