Приказ основних података о документу

dc.creatorOpsenica, Dejan
dc.creatorTerzić-Jovanović, Nataša
dc.creatorSmith, P.L.
dc.creatorYang, Y.
dc.creatorAnova, L.
dc.creatorSmith, K. S.
dc.creatorŠolaja, Bogdan
dc.date.accessioned2019-01-30T17:18:25Z
dc.date.available2019-01-30T17:18:25Z
dc.date.issued2008
dc.identifier.issn0968-0896
dc.identifier.urihttps://cer.ihtm.bg.ac.rs/handle/123456789/444
dc.description.abstractEleven new tetraoxanes possessing cholic acid-derived carrier and isopropylidene moiety were synthesized and were tested in vitro and in vivo. In vitro screening revealed that nine of them were more potent against CQ-resistant W2 than CQ-susceptible D6 strain and that two of them were equally or more potent than artemisinin and mefloquine against multi-drug resistant TM91C235 strain. Amine 8 cured all mice at the dose of 160 mg/kg/day, while the anilide 9 exhibited MCD ≤ 20 mg/kg/day. The diol 13 was most potent antiproliferative with GI50, TGI, LC50 MG_MID 0.98 μM, 3.80 μM, 11.22 μM, respectively. All tested compounds showed no toxic effects.en
dc.publisherOxford : Pergamon-Elsevier Science Ltd
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/142022/RS//
dc.rightsrestrictedAccess
dc.sourceBioorganic and Medicinal Chemistry
dc.subjectAntimalarialsen
dc.subjectAntiproliferativesen
dc.subjectCholic aciden
dc.subjectMetabolic stabilityen
dc.subjectMixed steroidal tetraoxanesen
dc.titleMixed tetraoxanes containing the acetone subunit as antimalarialsen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractТерзић Јовановић, Наташа; Yанг, Y.; Aнова, Л.; Опсеница, Дејан; Смитх, К.С.; Шолаја, Б.A.; Смитх, П.Л.;
dc.citation.volume16
dc.citation.issue14
dc.citation.spage7039
dc.citation.epage7045
dc.citation.other16(14): 7039-7045
dc.citation.rankM21
dc.identifier.pmid18550377
dc.identifier.doi10.1016/j.bmc.2008.05.017
dc.identifier.scopus2-s2.0-48949115566
dc.identifier.wos000257829600042
dc.type.versionpublishedVersion


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Приказ основних података о документу