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Mixed tetraoxanes containing the acetone subunit as antimalarials
dc.creator | Opsenica, Dejan | |
dc.creator | Terzić-Jovanović, Nataša | |
dc.creator | Smith, P.L. | |
dc.creator | Yang, Y. | |
dc.creator | Anova, L. | |
dc.creator | Smith, K. S. | |
dc.creator | Šolaja, Bogdan | |
dc.date.accessioned | 2019-01-30T17:18:25Z | |
dc.date.available | 2019-01-30T17:18:25Z | |
dc.date.issued | 2008 | |
dc.identifier.issn | 0968-0896 | |
dc.identifier.uri | https://cer.ihtm.bg.ac.rs/handle/123456789/444 | |
dc.description.abstract | Eleven new tetraoxanes possessing cholic acid-derived carrier and isopropylidene moiety were synthesized and were tested in vitro and in vivo. In vitro screening revealed that nine of them were more potent against CQ-resistant W2 than CQ-susceptible D6 strain and that two of them were equally or more potent than artemisinin and mefloquine against multi-drug resistant TM91C235 strain. Amine 8 cured all mice at the dose of 160 mg/kg/day, while the anilide 9 exhibited MCD ≤ 20 mg/kg/day. The diol 13 was most potent antiproliferative with GI50, TGI, LC50 MG_MID 0.98 μM, 3.80 μM, 11.22 μM, respectively. All tested compounds showed no toxic effects. | en |
dc.publisher | Oxford : Pergamon-Elsevier Science Ltd | |
dc.relation | info:eu-repo/grantAgreement/MESTD/MPN2006-2010/142022/RS// | |
dc.rights | restrictedAccess | |
dc.source | Bioorganic and Medicinal Chemistry | |
dc.subject | Antimalarials | en |
dc.subject | Antiproliferatives | en |
dc.subject | Cholic acid | en |
dc.subject | Metabolic stability | en |
dc.subject | Mixed steroidal tetraoxanes | en |
dc.title | Mixed tetraoxanes containing the acetone subunit as antimalarials | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Терзић Јовановић, Наташа; Yанг, Y.; Aнова, Л.; Опсеница, Дејан; Смитх, К.С.; Шолаја, Б.A.; Смитх, П.Л.; | |
dc.citation.volume | 16 | |
dc.citation.issue | 14 | |
dc.citation.spage | 7039 | |
dc.citation.epage | 7045 | |
dc.citation.other | 16(14): 7039-7045 | |
dc.citation.rank | M21 | |
dc.identifier.pmid | 18550377 | |
dc.identifier.doi | 10.1016/j.bmc.2008.05.017 | |
dc.identifier.scopus | 2-s2.0-48949115566 | |
dc.identifier.wos | 000257829600042 | |
dc.type.version | publishedVersion |