Приказ основних података о документу
X-ray crystal structure of 10β-hydroxy-4β,5β-epoxyestr-1-en3,17-dione and antitumor activity of its congeners
dc.creator | Milić, Dragana | |
dc.creator | Kapor, Agneš J. | |
dc.creator | Markov, Borislava | |
dc.creator | Ribar, Bela J. | |
dc.creator | Strümpel, Marianna Katona | |
dc.creator | Juranić, Zorica | |
dc.creator | Gašić, Miroslav J. | |
dc.creator | Šolaja, Bogdan | |
dc.date.accessioned | 2021-03-30T08:48:39Z | |
dc.date.available | 2021-03-30T08:48:39Z | |
dc.date.issued | 1999 | |
dc.identifier.issn | 1420-3049 | |
dc.identifier.uri | https://cer.ihtm.bg.ac.rs/handle/123456789/4405 | |
dc.description.abstract | Based on the biological properties of epoxyquinols from natural sources, the title compound was synthesised as a potential antitumor agent. Its molecular structure was partially confirmed by NMR studies. The detailed structure was established by X-ray analysis revealing two symmetry independent molecules in the asymmetric unit each consisting of four fused rings with the C(10) β-oriented hydroxy group and β-oriented O atom bridging C(4) and C(5). The conformation of A ring in both conformers A and B is boat (B3,6 ), while rings B and C are chairs (1C4) and the five-membered D ring is in an envelope (E2) conformation. The in vitro antitumor activity of title compound and its 17β-acetoxy analogue against HeLa and Fem-x cells revealed IC50 values of 5.7 and 7.1 μM, and 2.25 and 1.58 μM, respectively. Corresponding quinols were tested on 47 cell lines with 10β-hydroxy-17β-acetoxyestra-1,4-dien-3-one being most active against leukemia SR cells (GI50 = 0.17 μM). | sr |
dc.language.iso | en | sr |
dc.publisher | MDPI | sr |
dc.relation | Federal Ministry of Science, project No.OSI 412 | sr |
dc.relation | Serbian Ministry of Science and Technology, project No 01E18 | sr |
dc.rights | openAccess | sr |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.source | Molecules | sr |
dc.subject | Antitumor activity | sr |
dc.subject | Epoxyquinol | sr |
dc.subject | Quinol | sr |
dc.subject | Steroids | sr |
dc.subject | X-ray crystallograph | sr |
dc.title | X-ray crystal structure of 10β-hydroxy-4β,5β-epoxyestr-1-en3,17-dione and antitumor activity of its congeners | sr |
dc.type | article | sr |
dc.rights.license | BY | sr |
dcterms.abstract | Милић, Драгана; Јуранић, Зорица Д.; Гашић, Мирослав Ј.; Шолаја, Богдан; Стрüмпел, Марианна Катона; Рибар, Бела Ј.; Марков, Борислава; Капор, Aгнеш Ј.; | |
dc.citation.volume | 4 | |
dc.citation.issue | 12 | |
dc.citation.spage | 338 | |
dc.citation.epage | 352 | |
dc.identifier.doi | 10.3390/41200338 | |
dc.identifier.fulltext | https://cer.ihtm.bg.ac.rs/bitstream/id/19694/bitstream_19694.pdf | |
dc.identifier.scopus | 2-s2.0-0000703525 | |
dc.identifier.wos | 000084728400001 | |
dc.type.version | publishedVersion | sr |