An efficient semisynthesis of 7-deoxypaclitaxel from taxine

dc.creator	Saičić, Radomir N.
dc.creator	Matović, Radomir
dc.date.accessioned	2019-01-30T17:09:45Z
dc.date.available	2019-01-30T17:09:45Z
dc.date.issued	2000
dc.identifier.issn	1470-4358
dc.identifier.uri	https://cer.ihtm.bg.ac.rs/handle/123456789/43
dc.description.abstract	A semisynthesis of 7-deoxypaclitaxel 4 is described, starting from taxine 6 - the most abundant naturally occurring taxane diterpene fraction. A key step in this transformation is a tandem reaction: stereoselective osmylation of cinnamic ester 14/intramolecularly assisted methanolysis of 16, which gives the key intermediate 5, along with the optically pure ester 17 - a precursor for the synthesis of the paclitaxel side-chain. In this way, the cinnamoyltaxicine 9 is converted into 7-deoxybaccatin III 25 in 11 steps, and in 15% overall yield.	en
dc.rights	restrictedAccess
dc.source	Journal of the Chemical Society, Perkin Transactions 1
dc.title	An efficient semisynthesis of 7-deoxypaclitaxel from taxine	en
dc.type	article
dc.rights.license	ARR
dcterms.abstract	Матовић, Радомир; Саичић, Р.Н.;
dc.citation.issue	1
dc.citation.spage	59
dc.citation.epage	65
dc.citation.other	(1): 59-65
dc.identifier.doi	10.1039/a907288h
dc.identifier.scopus	2-s2.0-52549119999
dc.identifier.wos	000084864000008
dc.type.version	publishedVersion