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dc.creatorSaičić, Radomir N.
dc.creatorMatović, Radomir
dc.date.accessioned2019-01-30T17:09:45Z
dc.date.available2019-01-30T17:09:45Z
dc.date.issued2000
dc.identifier.issn1470-4358
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/43
dc.description.abstractA semisynthesis of 7-deoxypaclitaxel 4 is described, starting from taxine 6 - the most abundant naturally occurring taxane diterpene fraction. A key step in this transformation is a tandem reaction: stereoselective osmylation of cinnamic ester 14/intramolecularly assisted methanolysis of 16, which gives the key intermediate 5, along with the optically pure ester 17 - a precursor for the synthesis of the paclitaxel side-chain. In this way, the cinnamoyltaxicine 9 is converted into 7-deoxybaccatin III 25 in 11 steps, and in 15% overall yield.en
dc.rightsrestrictedAccess
dc.sourceJournal of the Chemical Society, Perkin Transactions 1
dc.titleAn efficient semisynthesis of 7-deoxypaclitaxel from taxineen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractМатовић, Радомир; Саичић, Р.Н.;
dc.citation.issue1
dc.citation.spage59
dc.citation.epage65
dc.citation.other(1): 59-65
dc.identifier.doi10.1039/a907288h
dc.identifier.rcubConv_4086
dc.identifier.scopus2-s2.0-52549119999
dc.identifier.wos000084864000008
dc.type.versionpublishedVersion


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