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Kinetika redukcije lipofilnog hinona avarona n-alkyl-1,4-di -hidronikotinamidima različite lipofilnosti

dc.creatorZlatović, Mario
dc.creatorGašić, Miroslav J.
dc.creatorSladić, Dušan
dc.date.accessioned2021-03-26T15:14:32Z
dc.date.available2021-03-26T15:14:32Z
dc.date.issued1999
dc.identifier.issn0352-5139
dc.identifier.issn1820-7421
dc.identifier.urihttps://cer.ihtm.bg.ac.rs/handle/123456789/4398
dc.description.abstractSeveral NADH model compounds, N-alkyl-1,4-dihydronicotinamides, some of them possessing amphiphilic properties, have been synthesized, and the kinetics of their reaction with a biologically active liphophilic quinone, avarone, has been studied in a protic solvent both in the presence and absence of cationic, anionic or non-ionic surfactants. In the absence of micellar agents, the medium-and long-chain N-dodecyl (3) and N-heptadecyl (4) derivatives show a significant increase in the reaction rates compared to other model compounds, due to the stabilization of the semiquinone intermediate. Anionic surfactants retard the reaction, non-ionic surfactants slightly accelerate the reaction with the short-chain derivatives, and retard the reaction with the medium-and long-chain derivatives, and the cationic surfactants increase the reaction rate with all derivatives except the long-chain 4. The results support the e-p-e mechanism of the reduction of lipophilic quinones by NADH models in protic medium.sr
dc.description.abstractSintetisano je nekoliko N-alkil-1,4-dihidronikotinamida, model-jedinjenja NADH, od kojih neki imaju amfifilne osobine, i proučavana je kinetika njihove reakcije sa biološkim aktivnim, lipofilnim hinonom avaronom u protinom rastvaraču u prisustvu katjonskih, anjonskih ili nejonskih površinski aktivnih supstanci i bez njh.Bez dodatih micelarnih agenasa, N-dodecil-derivat 3 (derivat srednje dužine niza) i dugolančani N-heptadecil-derivat 4 pokazuju značajno povećanje brzine reakcije u poređenju sa drugim model-jedinjenjima, usled stabilizacije semihinonskih intermedijera. Anjonski površinski aktivni agensi usporavaju reakciju, nejonski agensi dovode do slabog ubrzanja sa derivatima kratkog alkilniza, a usporavaju reak ciju sa derivatima srednjeg i dugog niza, dok katjonski agensi ubrzavaju reakciju sa svim derivatima, sem sa dugolančanim 4. Rezultati ukazuju na mehanizam e-p-e redukcije lipofilnih hinona modelima NADH u protičnom medijumu.sr
dc.language.isoensr
dc.publisherBelgrade : Serbian Chemical Societysr
dc.rightsopenAccesssr
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceJournal of the Serbian Chemical Societysr
dc.subjectAvaronesr
dc.subjectKineticssr
dc.subjectNADH modelssr
dc.subjectQuinonesr
dc.subjectSurfactantssr
dc.titleThe kinetics of the reduction of the lipophilic quinone avarone by n-alkyl-1,4-dihydronicotinamides of various lipophilicitiessr
dc.titleKinetika redukcije lipofilnog hinona avarona n-alkyl-1,4-di -hidronikotinamidima različite lipofilnostisr
dc.typearticlesr
dc.rights.licenseBY-NC-NDsr
dcterms.abstractЗлатовић, Марио В.; Гашић, Мирослав Ј.; Сладић, Душан М.;
dc.citation.volume64
dc.citation.issue11
dc.citation.spage647
dc.citation.epage654
dc.identifier.doi10.2298/JSC9911647Z
dc.identifier.fulltexthttps://cer.ihtm.bg.ac.rs/bitstream/id/19677/0352-51399911647Z.pdf
dc.identifier.scopus2-s2.0-0033263339
dc.identifier.wos000083803100001
dc.type.versionpublishedVersionsr


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