Synthesis and evaluation of several cathechol bioisosteres as potential dopamine receptor ligands

dc.creator	Kostić, Slađana
dc.creator	Šoškić, Vukić
dc.creator	Joksimović, Jelena
dc.date.accessioned	2021-03-23T08:09:50Z
dc.date.available	2021-03-23T08:09:50Z
dc.date.issued	1991
dc.identifier.issn	0960-894X
dc.identifier.issn	1464-3405
dc.identifier.uri	https://cer.ihtm.bg.ac.rs/handle/123456789/4384
dc.description.abstract	Derivatives of benzimidazole (I), benzimidazolone (II), benzimidazolethione (III), 2,3-dihydroxyquinoxaline (IV) and the noncyclic acetamide (V) and t rifluoroacetamide (VI) of the corresponding 1,2-pheny-lenediamiane were synthesized and tested for DA-ergic activity. III and IV had a moderate affini ty for the D2 receptors of the bovine caudate nucleus. Several potential DA-receptor ligands were synthesized. III and IV expressed the affinity for the D-2 receptor.	sr
dc.language.iso	en	sr
dc.publisher	Elsevier	sr
dc.relation	The Research Science Funds of Serbia, Grant No. 8016.	sr
dc.rights	restrictedAccess	sr
dc.source	Bioorganic and Medicinal Chemistry Letters	sr
dc.subject	dopamine	sr
dc.subject	drug synthesis	sr
dc.subject	drug receptor binding	sr
dc.subject	D-2 receptor	sr
dc.title	Synthesis and evaluation of several cathechol bioisosteres as potential dopamine receptor ligands	sr
dc.type	article	sr
dc.rights.license	ARR	sr
dc.citation.volume	1
dc.citation.issue	8
dc.citation.spage	403
dc.citation.epage	406
dc.identifier.doi	10.1016/S0960-894X(00)80265-6
dc.identifier.scopus	2-s2.0-0026002989
dc.type.version	publishedVersion	sr