Derivatives of benzimidazole (I), benzimidazolone (II), benzimidazolethione (III), 2,3-dihydroxyquinoxaline (IV) and the noncyclic acetamide (V) and t rifluoroacetamide (VI) of the corresponding 1,2-pheny-lenediamiane were synthesized and tested for DA-ergic activity. III and IV had a moderate affini ty for the D2 receptors of the bovine caudate nucleus. Several potential DA-receptor ligands were synthesized. III and IV expressed the affinity for the D-2 receptor.
Keywords:
dopamine / drug synthesis / drug receptor binding / D-2 receptor
Source:
Bioorganic and Medicinal Chemistry Letters, 1991, 1, 8, 403-406
Publisher:
Elsevier
Funding / projects:
The Research Science Funds of Serbia, Grant No. 8016.
TY - JOUR
AU - Kostić, Slađana
AU - Šoškić, Vukić
AU - Joksimović, Jelena
PY - 1991
UR - https://cer.ihtm.bg.ac.rs/handle/123456789/4384
AB - Derivatives of benzimidazole (I), benzimidazolone (II), benzimidazolethione (III), 2,3-dihydroxyquinoxaline (IV) and the noncyclic acetamide (V) and t rifluoroacetamide (VI) of the corresponding 1,2-pheny-lenediamiane were synthesized and tested for DA-ergic activity. III and IV had a moderate affini ty for the D2 receptors of the bovine caudate nucleus. Several potential DA-receptor ligands were synthesized. III and IV expressed the affinity for the D-2 receptor.
PB - Elsevier
T2 - Bioorganic and Medicinal Chemistry Letters
T1 - Synthesis and evaluation of several cathechol bioisosteres as potential dopamine receptor ligands
VL - 1
IS - 8
SP - 403
EP - 406
DO - 10.1016/S0960-894X(00)80265-6
ER -
@article{
author = "Kostić, Slađana and Šoškić, Vukić and Joksimović, Jelena",
year = "1991",
abstract = "Derivatives of benzimidazole (I), benzimidazolone (II), benzimidazolethione (III), 2,3-dihydroxyquinoxaline (IV) and the noncyclic acetamide (V) and t rifluoroacetamide (VI) of the corresponding 1,2-pheny-lenediamiane were synthesized and tested for DA-ergic activity. III and IV had a moderate affini ty for the D2 receptors of the bovine caudate nucleus. Several potential DA-receptor ligands were synthesized. III and IV expressed the affinity for the D-2 receptor.",
publisher = "Elsevier",
journal = "Bioorganic and Medicinal Chemistry Letters",
title = "Synthesis and evaluation of several cathechol bioisosteres as potential dopamine receptor ligands",
volume = "1",
number = "8",
pages = "403-406",
doi = "10.1016/S0960-894X(00)80265-6"
}
Kostić, S., Šoškić, V.,& Joksimović, J.. (1991). Synthesis and evaluation of several cathechol bioisosteres as potential dopamine receptor ligands. in Bioorganic and Medicinal Chemistry Letters
Elsevier., 1(8), 403-406.
https://doi.org/10.1016/S0960-894X(00)80265-6
Kostić S, Šoškić V, Joksimović J. Synthesis and evaluation of several cathechol bioisosteres as potential dopamine receptor ligands. in Bioorganic and Medicinal Chemistry Letters. 1991;1(8):403-406.
doi:10.1016/S0960-894X(00)80265-6 .
Kostić, Slađana, Šoškić, Vukić, Joksimović, Jelena, "Synthesis and evaluation of several cathechol bioisosteres as potential dopamine receptor ligands" in Bioorganic and Medicinal Chemistry Letters, 1, no. 8 (1991):403-406,
https://doi.org/10.1016/S0960-894X(00)80265-6 . .
