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Synthesis and in vitro antitumoral activity of novel O,O′-di-2-alkyl-(S,S)-ethylenediamine-N,N′-di-2-propanoate ligands and corresponding platinum(II/IV) complexes
dc.creator | Krajčinović, Bojana B. | |
dc.creator | Kaluđerović, Goran N. | |
dc.creator | Steinborn, Dirk | |
dc.creator | Schmidt, Harry | |
dc.creator | Wagner, Christoph | |
dc.creator | Žižak, Željko | |
dc.creator | Juranić, Zorica | |
dc.creator | Trifunović, Srećko R. | |
dc.creator | Sabo, Tibor | |
dc.date.accessioned | 2021-03-08T09:50:10Z | |
dc.date.available | 2021-03-08T09:50:10Z | |
dc.date.issued | 2008 | |
dc.identifier.issn | 0162-0134 | |
dc.identifier.issn | 1873-3344 | |
dc.identifier.uri | https://cer.ihtm.bg.ac.rs/handle/123456789/4330 | |
dc.description.abstract | Syntheses of two novel ligand precursors O,O′-diisopropyl- (1a) and O,O′-diisobutyl-(S,S)-ethylenediamine-N,N′-di-2-propanoate dihydrochloride monohydrate (1b) and the corresponding dichloroplatinum(II) (2a and 2b) and tetrachloroplatinum(IV) complexes (3a and 3b) are described here. The substances were characterized by IR, 1H and 13C spectroscopy and elemental analysis. Crystal structures were determined for 1a and the corresponding platinum(IV) complex, 3a. In vitro antiproliferative activity was determined against tumor cell lines: human adenocarcinoma HeLa, human myelogenous leukemia K562, human malignant melanoma Fem-x, rested and stimulated normal immunocompetent cells (human peripheral blood mononuclear PBMC cells) using KBR test (Kenacid Blue Dye binding test). The IC50(μM) values for the most active compound 3a were: 30.48 ± 2.54; 12.26 ± 2.60; 13.68 ± 3.22; 80.18 ± 24.07 and 71.30 ± 21.70, respectively. | sr |
dc.language.iso | en | sr |
dc.publisher | Elsevier | sr |
dc.relation | info:eu-repo/grantAgreement/MESTD/MPN2006-2010/142010/RS// | sr |
dc.relation | info:eu-repo/grantAgreement/MESTD/MPN2006-2010/145006/RS// | sr |
dc.relation | info:eu-repo/grantAgreement/MESTD/MPN2006-2010/142008/RS// | sr |
dc.rights | restrictedAccess | sr |
dc.source | Journal of Inorganic Biochemistry | sr |
dc.subject | Antitumoral activity | sr |
dc.subject | Edda ligands | sr |
dc.subject | Platinum(II) complexes | sr |
dc.subject | Platinum(IV) complexes | sr |
dc.title | Synthesis and in vitro antitumoral activity of novel O,O′-di-2-alkyl-(S,S)-ethylenediamine-N,N′-di-2-propanoate ligands and corresponding platinum(II/IV) complexes | sr |
dc.type | article | sr |
dc.rights.license | ARR | sr |
dcterms.abstract | Трифуновић, Срећко Р.; Сабо, Тибор; Јуранић, Зорица; Жижак, Жељко; Калуђеровић, Горан Н.; Крајчиновић, Бојана Б.; Wагнер, Цхристопх; Сцхмидт, Харрy; Стеинборн, Дирк; | |
dc.citation.volume | 102 | |
dc.citation.issue | 4 | |
dc.citation.spage | 892 | |
dc.citation.epage | 900 | |
dc.citation.rank | M21 | |
dc.identifier.doi | 10.1016/j.jinorgbio.2007.12.009 | |
dc.identifier.scopus | 2-s2.0-40849120528 | |
dc.identifier.wos | 000255131500031 | |
dc.type.version | publishedVersion | sr |