Приказ основних података о документу

dc.creatorLović, Jelena
dc.creatorTrišović, Nemanja
dc.creatorAntanasijevic, Jelena
dc.creatorNikolić, Nebojša D.
dc.creatorStevanović, Sanja
dc.creatorMijin, Dušan
dc.creatorVukovic, Dragan
dc.creatorMladenović, Aleksandar R.
dc.creatorPetrović, Slobodan D.
dc.creatorAvramov Ivić, Milka
dc.date.accessioned2021-03-05T09:10:34Z
dc.date.available2018-10-13
dc.date.issued2016
dc.identifier.issn1572-6657
dc.identifier.urihttps://cer.ihtm.bg.ac.rs/handle/123456789/4310
dc.description.abstractNonmedical use of sildenafil citrate (SC) requires new methods for drug determination in human serum and in tablets. SC as standard and in Sildena (R) tablets is determined by square wave voltammetry (SWV) in 0.1 M H2SO4 (harmful for human serum) at gold electrode in a range: (1 x 10(-3),1 x 10(-2), 0.1, 0.5,1) mu M and on cysteine (Cys) modified gold electrode (Au/Cys) in a range: (1 x 10(-3),1 x 10(-2), 0.05, 0.1) mu M. The presence of Cys causes two times larger peak currents and shifting of the incipient potential of the SC oxidation to 0.1 V in negative direction. A safe procedure for SC determination as standard and in Sildena (R) tablets spiked with human serum is developed by SWV at gold electrode in 0.05 M NaHCO3 (suitable for human liquids) in a range: (1 x 10(-3),1 x 10(-2), 0.1, 0.2, 03) mu M. Microscopic characterization of the surfaces morphology was also performed. The SC concentrations were checked by high performance liquid chromatography-ultraviolet spectroscopy (HPLC-UV) showing that electrochemical method is more sensitive and can be used for the measurements of very low concentrations of the analyte.en
dc.publisherElsevier
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172013/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172060/RS//
dc.relation.isversionofhttps://cer.ihtm.bg.ac.rs/handle/123456789/1902
dc.rightsembargoedAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceJournal of Electroanalytical Chemistry
dc.subjectSildenafil citrateen
dc.subjectAu/Cys electrodeen
dc.subjectHuman serum analysisen
dc.subjectSurface microscopic analysisen
dc.titleElectrochemical determination of sildenafil citrate as standard, in tablets and spiked with human serum at gold and cystein modified gold electrodeen
dc.typearticle
dc.rights.licenseBY-NC-ND
dcterms.abstractПетровић, Слободан Д.; Младеновић, Aлександар Р.; Aврамов Ивић, Милка; Николић, Небојша Д.; Вуковиц, Драган; Мијин, Душан; Стевановић, Сања; Aнтанасијевиц, Јелена; Тришовић, Немања; Ловић, Јелена;
dc.citation.volume782
dc.citation.spage103
dc.citation.epage107
dc.citation.other782: 103-107
dc.citation.rankM21
dc.description.otherThis is the peer-reviewed version of the article: Lović, J., Trišović, N., Antanasijevic, J., Nikolić, N. D., Stevanović, S., Mijin, D., Vukovic, D., Mladenović, A. R., Petrović, S. D.,& Avramov Ivić, M. (2016). Electrochemical determination of sildenafil citrate as standard, in tablets and spiked with human serum at gold and cystein modified gold electrode. Journal of Electroanalytical Chemistry, Elsevier., 782, 103-107. [https://doi.org/10.1016/j.jelechem.2016.10.022]
dc.description.otherThe published version: [https://cer.ihtm.bg.ac.rs/handle/123456789/1902]
dc.identifier.doi10.1016/j.jelechem.2016.10.022
dc.identifier.fulltexthttps://cer.ihtm.bg.ac.rs/bitstream/id/19392/1902.acc.pdf
dc.identifier.scopus2-s2.0-84992195164
dc.identifier.wos000390510000015
dc.type.versionacceptedVersion


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Приказ основних података о документу