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dc.creatorDilber, Sanda P.
dc.creatorŽižak, Željko
dc.creatorStanojković, Tatjana
dc.creatorJuranić, Zorica
dc.creatorDrakulić, Branko
dc.date.accessioned2021-03-03T11:10:08Z
dc.date.available2021-03-03T11:10:08Z
dc.date.issued2007
dc.identifier.issn1661-6596
dc.identifier.issn1422-0067
dc.identifier.urihttps://cer.ihtm.bg.ac.rs/handle/123456789/4305
dc.description.abstractArticle describes the synthesis of fifteen β-hydroxy- β-arylalkanoic acids by Reformatsky reaction using the 1-ethoxyethyl-2- bromoalkanoates, aromatic or cycloalkyl ketones or aromatic aldehydes. The short survey of previously reported synthetic procedures for title compounds, is given. The majority of obtained compounds exert antiproliferative activity in vitro toward human: HeLa, Fem-X cells, K562, and LS174 cells, having IC 50 values from 62.20 to 205 μM. The most active compound is 3-OH-2,2-di-Me-3-(4-biphenylyl)-butanoic acid, having the IC 50 value 62.20 μM toward HeLa cells. Seven examined compounds did not affect proliferation of healthy human blood peripheral mononuclear cells (PBMC and PBMC+ PHA), IC 50 > 300 μM. The preliminary QSAR results show that estimated lipophilicity of compounds influences their antiproliferative activity in the first place. The ability of dehydration, and the spatial arrangement of hydrophobic portion, HBD and HBA in molecules are has almost equal importance as lipophilicity.sr
dc.language.isoensr
dc.publisherMDPIsr
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/142010/RS//sr
dc.rightsopenAccesssr
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceInternational Journal of Molecular Sciencessr
dc.subjectβ-hydroxy-β-arylalkanoic acidssr
dc.subjectAntiproliferative activitysr
dc.subjectHuman dedifferentiate cellssr
dc.subjectQSARsr
dc.subjectReformatsky reactionsr
dc.subjectAntiproliferativna aktivnostsr
dc.titleAntiproliferative activity of β-hydroxy- β-arylalkanoic acidssr
dc.typearticlesr
dc.rights.licenseBYsr
dcterms.abstractСтанојковић, Татјана П.; Дилбер, Санда П.; Зизак, Зељко; Јуранич, Зорица Д.; Дракулић, Бранко Ј.; Дракулић, Бранко Ј.;
dc.citation.volume8
dc.citation.issue3
dc.citation.spage214
dc.citation.epage228
dc.citation.rankM22
dc.identifier.doi10.3390/i8030214
dc.identifier.fulltexthttps://cer.ihtm.bg.ac.rs/bitstream/id/19369/ijms-08-00214.pdf
dc.identifier.scopus2-s2.0-34047235830
dc.identifier.wos000245396500004
dc.type.versionpublishedVersionsr


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