Biocompatible and degradable scaffolds based on 2-hydroxyethyl methacrylate, gelatin and poly(beta amino ester) crosslinkers
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Метаподаци
Приказ свих података о документуАпстракт
Gelatin hydrogels have great potential in regenerative medicine but their weak mechanical properties are a major drawback for the load-bearing applications, such as scaffolds for tissue engineering. To overcome this deficiency, novel biodegradable hydrogels with improved mechanical properties were prepared by combining gelatine with 2-hydroxyethyl methacrylate (HEMA), using a double network synthetic procedure. The first, superporous and mechanically strong network, was obtained by free radical polymerization of HEMA at cryogenic temperature, in the presence of gelatin. Degradable poly (beta-amino ester) (PBAE) macromers of different chemical composition or molecular weight were used as crosslinkers to introduce hydrolytically labile bonds in PHEMA. The second gelatin network was formed by crosslinking gelatin with glutaraldehyde. For comparison, a set of biodegradable PHEMA networks was obtained by polymerization of HEMA at cryogenic temperature. All samples were characterized reveali...ng that mechanical strength, swelling behavior and degradation rate as well as high biocompatibility of new IPNs are in accordance with values required for scaffolds in tissue engineering applications and that tuning of these properties is accomplished by simply using different PBAE macromers.
Кључне речи:
HEMA / PBAE / Biocompatible / Degradable / Porous scaffoldsИзвор:
Polymer Testing, 2018, 68, 270-278Издавач:
- Elsevier
Финансирање / пројекти:
- SCOPES programme of the Swiss National Science Foundation
- Swiss Agency for Development and Cooperation - IZ73ZO_152327
- Синтеза и карактеризација нових функционалних полимера и полимерних нанокомпозита (RS-MESTD-Basic Research (BR or ON)-172062)
- Геолошка и екотоксиколошка истраживања у идентификацији геопатогених зона токсичних елемената у акумулацијама воде за пиће - истраживање метода и поступака смањивања утицаја биогеохемијских аномалија (RS-MESTD-Basic Research (BR or ON)-176018)
Напомена:
- This is peer-reviewed version of the article: Filipović, V., Nedeljkovic, B. D. B., Vukomanovic, M.,& Tomić, S. Lj. (2018). Biocompatible and degradable scaffolds based on 2-hydroxyethyl methacrylate, gelatin and poly(beta amino ester) crosslinkers. Polymer TestingElsevier Sci Ltd, Oxford., 68, 270-278. https://doi.org/10.1016/j.polymertesting.2018.04.024
- The published version: https://cer.ihtm.bg.ac.rs/handle/123456789/2440
DOI: 10.1016/j.polymertesting.2018.04.024
ISSN: 0142-9418
WoS: 000437076000034
Scopus: 2-s2.0-85046032696
Институција/група
IHTMTY - JOUR AU - Filipović, Vuk AU - Nedeljkovic, Biljana D. Bozic AU - Vukomanović, Marija AU - Tomić, Simonida Lj. PY - 2018 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/4293 AB - Gelatin hydrogels have great potential in regenerative medicine but their weak mechanical properties are a major drawback for the load-bearing applications, such as scaffolds for tissue engineering. To overcome this deficiency, novel biodegradable hydrogels with improved mechanical properties were prepared by combining gelatine with 2-hydroxyethyl methacrylate (HEMA), using a double network synthetic procedure. The first, superporous and mechanically strong network, was obtained by free radical polymerization of HEMA at cryogenic temperature, in the presence of gelatin. Degradable poly (beta-amino ester) (PBAE) macromers of different chemical composition or molecular weight were used as crosslinkers to introduce hydrolytically labile bonds in PHEMA. The second gelatin network was formed by crosslinking gelatin with glutaraldehyde. For comparison, a set of biodegradable PHEMA networks was obtained by polymerization of HEMA at cryogenic temperature. All samples were characterized revealing that mechanical strength, swelling behavior and degradation rate as well as high biocompatibility of new IPNs are in accordance with values required for scaffolds in tissue engineering applications and that tuning of these properties is accomplished by simply using different PBAE macromers. PB - Elsevier T2 - Polymer Testing T1 - Biocompatible and degradable scaffolds based on 2-hydroxyethyl methacrylate, gelatin and poly(beta amino ester) crosslinkers VL - 68 SP - 270 EP - 278 DO - 10.1016/j.polymertesting.2018.04.024 ER -
@article{ author = "Filipović, Vuk and Nedeljkovic, Biljana D. Bozic and Vukomanović, Marija and Tomić, Simonida Lj.", year = "2018", abstract = "Gelatin hydrogels have great potential in regenerative medicine but their weak mechanical properties are a major drawback for the load-bearing applications, such as scaffolds for tissue engineering. To overcome this deficiency, novel biodegradable hydrogels with improved mechanical properties were prepared by combining gelatine with 2-hydroxyethyl methacrylate (HEMA), using a double network synthetic procedure. The first, superporous and mechanically strong network, was obtained by free radical polymerization of HEMA at cryogenic temperature, in the presence of gelatin. Degradable poly (beta-amino ester) (PBAE) macromers of different chemical composition or molecular weight were used as crosslinkers to introduce hydrolytically labile bonds in PHEMA. The second gelatin network was formed by crosslinking gelatin with glutaraldehyde. For comparison, a set of biodegradable PHEMA networks was obtained by polymerization of HEMA at cryogenic temperature. All samples were characterized revealing that mechanical strength, swelling behavior and degradation rate as well as high biocompatibility of new IPNs are in accordance with values required for scaffolds in tissue engineering applications and that tuning of these properties is accomplished by simply using different PBAE macromers.", publisher = "Elsevier", journal = "Polymer Testing", title = "Biocompatible and degradable scaffolds based on 2-hydroxyethyl methacrylate, gelatin and poly(beta amino ester) crosslinkers", volume = "68", pages = "270-278", doi = "10.1016/j.polymertesting.2018.04.024" }
Filipović, V., Nedeljkovic, B. D. B., Vukomanović, M.,& Tomić, S. Lj.. (2018). Biocompatible and degradable scaffolds based on 2-hydroxyethyl methacrylate, gelatin and poly(beta amino ester) crosslinkers. in Polymer Testing Elsevier., 68, 270-278. https://doi.org/10.1016/j.polymertesting.2018.04.024
Filipović V, Nedeljkovic BDB, Vukomanović M, Tomić SL. Biocompatible and degradable scaffolds based on 2-hydroxyethyl methacrylate, gelatin and poly(beta amino ester) crosslinkers. in Polymer Testing. 2018;68:270-278. doi:10.1016/j.polymertesting.2018.04.024 .
Filipović, Vuk, Nedeljkovic, Biljana D. Bozic, Vukomanović, Marija, Tomić, Simonida Lj., "Biocompatible and degradable scaffolds based on 2-hydroxyethyl methacrylate, gelatin and poly(beta amino ester) crosslinkers" in Polymer Testing, 68 (2018):270-278, https://doi.org/10.1016/j.polymertesting.2018.04.024 . .